DOSE-DEPENDENT INDUCTION OF CARCINOMAS AND GLUTATHIONE S-TRANSFERASE PLACENTAL FORM NEGATIVE EOSINOPHILIC FOCI IN THE RAT LIVER BY DI(2-ETHYLHEXYL)PHTHALATE AFTER DIETHYLNITROSAMINE INITIATION
スポンサーリンク
概要
- 論文の詳細を見る
The dose-dependence of di(2-ethylhexyl)phthalate (DEHP) hepatocarcinogenicity was investigated in male F344 rats which were initially injected with diethylnitrosamine (200 mg/kg, hp) and subjected to partial hepatectomy at week 3. The animals were administered DEHP in the diet at concentrations of 30, 300, 3000, or 12000 ppm starting 2 weeks after the DEN injection for up to 46 weeks and killed at weeks 8, 24, 48 and 52. Additional groups were given clofibrate (3000 ppm in diet) or basal diet instead of the DEHP diet. Incidences of hepatocellular carcinomas were 75% (9/12, P<0.01) for 12000 ppm, 10% (1/10) for 3000 ppm, 7% (1/14) for 300 ppm, 0% (0/13) for 30 ppm, 15% (2/13) for clofibrate, and 8% (1/13) for the basal diet group at week 52, 4 weeks after cessation of chemical feeding. Development of glutathione S-transferase placental form (GST-P) positive foci was only slightly increased by clofibrate-administration at week 52 and consistently lower than the control level in the DEHP-treated groups after 24 weeks. In contrast, GST-P negative eosinophilic foci were dose-dependently increased in the more than 300 ppm DEHP and clofibrate treated groups. At the 30 ppm dose level, however, no morphological changes were apparent in the liver. Thus, the non-observed effect level regarding the promotional activity of hepatocarcinogenesis was demonstrated at 30 ppm, the effects being predictable on the basis of development of GST-P negative eosinophilic foci.
- 日本トキシコロジー学会の論文
- 1999-08-17
著者
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IMAI Norio
DIMS Institute of Medical Science, Inc.
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Inada Ken-ichi
Department Of Pathology Fujita Health University School Of Medicine
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Sano Masashi
DIMS Institute of Medical Science, Inc.
-
Imai Norio
Dims Institute Of Medical Science Inc.
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Imai Norio
Dims医科学研究所
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Imai N
Department Of Experimental Pathology And Tumor Biology Nagoya City University Medical Sciences
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Hagiwara A
Dims Institute Of Medical Science Inc.
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Hagiwara Akihiro
Dims医科学研究所
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IMAIDA Katsumi
Onco-Pathology, Faculty of Medicine, Department of Pathology and Host-Defense, Kagawa University
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TAMANO Seiko
Daiyu-Kai Institute of Medical Science, Inc.
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ITO Nobuyuki
Nagoya City University
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HAGIWARA Akihiro
Daiyu-kai Institute of Medical Science
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IMAI NORIO
Daiyu-kai Institute of Medical Science
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Inaguma Shingo
大雄会医科学研究所
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SANO Masashi
First Department of Pathology, Nagoya City University Medical School
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SHIRAI Tomoyuki
First Department of Pathology, Nagoya City University Medical School
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HASEGAWA Ryohei
First Department of Pathology, Nagoya City University Medical School
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Imaida K
Onco-pathology Faculty Of Medicine Department Of Pathology And Host-defense Kagawa University
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Imaida Katsumi
国立がんセンター研究所 がん予防基礎研究プロジェクト
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Hasegawa R
First Department Of Pathology Nagoya City University Medical School
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Imaida Katsumi
大雄会医科学研究所
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Inada Ken-ichi
愛知県がんセンター研究所 腫瘍病理学部
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稲田 健一
Department Of Pathology Fujita Health University School Of Medicine
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Shibata Masa-aki
First Department Of Pathology Nagoya City University Medical School
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IMAIDA Katsumi
First Department of Pathology, Nagoya City University Medical School
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SHIBATA Masa-Aki
Daiyu-kai Institute of Medical Science
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Tamano Seiko
Daiyu-kai Institute Of Medical Science Ichinomiya Japan
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Sano M
Dims Institute Of Medical Science Inc.
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Shirai Tomoyuki
First Department Of Pathology Nagoya City University Medical School
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Hasegawa Ryouhei
First Department Of Pathology Nagoya City University Medical School
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Shibata Michiko
First Department Of Pathology Nagoya City University Medical School
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Hasegawa Ryohei
First Department Of Pathology Nagoya City University Medical School
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Ito Nobuyuki
First Department Of Pathology Nagoya City University Medical School
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Sano Masaki
Cancer Research Laboratory Taiho Pharmaceutical Co. Ltd.
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Shibata Masa-aki
1st Dept.pathol. Nagoya City Univ.med.sch.
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Shibata Michiko
Development Strategy Department Yamanouchi Pharmaceutical Co. Ltd.
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Hagihara Atsushi
Department Of Pathology Osaka City University Medical School
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Imaida Katsumi
First Department Of Pathology Nagoya City University Medical School
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Shibata Masaaki
First Department Of Pathology Nagoya City University Medical School
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Hagiwara Akihiro
First Department Of Pathology Nagoya City University Medical School
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Ito N
Nagoya City Univ. Nagoya
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Tamano Seiko
Daiyu-kai Institute Of Medical Science
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