Inhibition of Angiotensin I-converting Enzyme by Bacillus licheniformis Alkaline Protease Hydrolyzates Derived from Sardine Muscle

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概要

• 論文の詳細を見る

• Hydrolyzates which inhibit the angiotensin I-converting enzyme (ACE) were prepared from sardine muscle by Bacillus licheniformis alkaline protease. Considering the practical application of preparations as a functional food material, the best proteolytic conditions with respect to taste, solubility and ACE inhibitory activity were a 0.3 wt% addition of the enzyme and 17-h proteolysis at 50℃ and pH 9.0. The preparations under these conditions had potent activity (IC_<50>=0.26 mg protein/ml). Fractionation of the preparations on an ODS column with ethanol resulted in the production of more potent inhibitors. The most potent activity was obtained when eluting with 10% ethanol (IC_<50>=0.015 mg protein/ml). This fraction was apparently rich in acidic amino acids, poor in hydrophobic ones, and effective for use as a physiologically functional food material by virtue of little bitterness, a fish odor and powerful ACE inhibitory activity.

• 社団法人日本農芸化学会の論文
• 1993-06-23

著者

• OSAJIMA Yutaka

  Department of Food Science and Technology, Faculty of Agriculture, Kyushu University

• Osajima Yutaka

  Department Of Bioresources And Biosciences Hiroshima Prefectural University

• Osajima Yutaka

  Kyushu Women's Univ.

• Matsui T

  Kyushu Univ. Fukuoka Jpn

• Matsui Toshiro

  Department Of Electrical And Electronic Engineering Tokyo Institute Of Technology

• Matsui Toshiro

  Department Of Applied Chemistry Faculty Of Engineering Doshisha University

• SEKI Eiji

  Senmi Ekisu Co.

• OSAJIMA Katsuhiro

  Senmi Ekisu Co.

• Osajima Y

  Kyushu Women's College

• Seki Eiji

  Department Of Agricultural Chemistry Gifu University

• Toshiro Matsui

  Faculty Of Agriculture Graduate School Kyushu University

• MATSUFUJI Hiroshi

  Department of Food Science and Technology, College of Bioresource Sciences, Nihon University (NUBS)

• MATSUFUJI Hiroshi

  Faculty of Agriculture, Kyushu University

• OSAJIMA Katsuhiro

  Research Laboratories, Senmi Ekisu Co.

• Seki Eiji

  Research Laboratories, Senmi Ekisu Co.

• Nakashima Masatoshi

  Department of Food Science and Technology, Faculty of Agriculture, Kyushu University

• Matsufuji Hiroshi

  Faculty Of Agriculture Kyushu University

• Matsufuji Hiroshi

  Department Of Food Bioscience And Biotechnology College Of Bioresource Sciences Nihon University

• Osajima Katsuhiro

  Research And Development Department Senmi Ekisu Co. Ltd.

• Nakashima Masatoshi

  Department Of Food Science And Technology Faculty Of Agriculture Kyushu University

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