Angiotensin I-converting Enzyme Inhibitory Peptides in an Alkaline Protease Hydrolyzate Derived from Sardine Muscle

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概要

• 論文の詳細を見る

• The ACE inhibitory activity of an alkaline protease hydrolyzate from sardine muscle did not change after being treated by gastrointestinal proteases (IC_50 = 0. 082 mg protein/ml). Eleven new ACE inhibitory peptides, constructed with 2 to 4 amino acid residues, were isolated from the hydrolyzate. The ACE inhibitory activity of each was mostly below 100μM of IC_50 value ; the maximal inhibitory activity was observed for Lys-Trp (IC_50 = 1. 63 μM). The isolated peptides inhibited ACE competitively, except for Met-Tyr with non-competitive inhibition. As the result of sequence homology, Arg-Val-Tyr isolated from the hydrolyzate was found in the primary structure of angiotensins I, II, and III, and of des Asp[1]-angiotensin I.

• 社団法人日本農芸化学会の論文
• 1994-12-23

著者

• OSAJIMA Yutaka

  Department of Food Science and Technology, Faculty of Agriculture, Kyushu University

• Osajima Y

  Kyushu Univ. Fukuoka Jpn

• Osajima Yutaka

  Department Of Bioresources And Biosciences Hiroshima Prefectural University

• Osajima Yutaka

  Kyushu Women's Univ.

• Matsui T

  Kyushu Univ. Fukuoka Jpn

• Matsui Toshiro

  Department Of Electrical And Electronic Engineering Tokyo Institute Of Technology

• Matsui Toshiro

  Department Of Applied Chemistry Faculty Of Engineering Doshisha University

• SEKI Eiji

  Senmi Ekisu Co.

• OSAJIMA Katsuhiro

  Senmi Ekisu Co.

• Osajima Y

  Kyushu Women's College

• Seki Eiji

  Department Of Agricultural Chemistry Gifu University

• Toshiro Matsui

  Faculty Of Agriculture Graduate School Kyushu University

• MATSUFUJI Hiroshi

  Department of Food Science and Technology, College of Bioresource Sciences, Nihon University (NUBS)

• MATSUFUJI Hiroshi

  Faculty of Agriculture, Kyushu University

• OSAJIMA Katsuhiro

  Research Laboratories, Senmi Ekisu Co.

• Seki Eiji

  Research Laboratories, Senmi Ekisu Co.

• Nakashima Masatoshi

  Department of Food Science and Technology, Faculty of Agriculture, Kyushu University

• Matsufuji Hiroshi

  Faculty Of Agriculture Kyushu University

• Matsufuji Hiroshi

  Department Of Food Bioscience And Biotechnology College Of Bioresource Sciences Nihon University

• Osajima Katsuhiro

  Research And Development Department Senmi Ekisu Co. Ltd.

• Nakashima Masatoshi

  Department Of Food Science And Technology Faculty Of Agriculture Kyushu University

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