Antihypertensive Effects of Angiotensin Fragments in SHR

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概要

• 論文の詳細を見る

• When angiotensin fragments, Val-Tyr and Angiotensin III (ANG III), with potent ACE inhibitory activity were intravenously administered to spontaneously hypertensive rat (SHR), a significant reduction of diastolic blood pressure was observed. After incubation of ANG III with SHR plasma, four fragments with ACE inhibitory activity, Val-Tyr (ANG (3-4)) (IC_<50>=26.0μM), Ile-His-Pro-Phe (ANG (5-8)) (11.6μM), Tyr-Ile-His-Pro-Phe (ANG (4-8)) (457.5μM), and Val-Tyr-Ile-His-Pro-Phe (ANG (3-8)) (6.55μM), were confirmed to generate in SHR plasma. Compared the metabolic behavior of ANG II in SHR plasma with that in normotensive Wistar plasma, the initial degradation rate (3.07nmol/ml/min) in Wistar plasma was about 2-fold higher than that in the SHR one (1.75nmol/ml/min).

• 社団法人日本農芸化学会の論文
• 1995-08-23

著者

• KAWASAKI Terukazu

  Institute of Health Science, Kyushu University

• OSAJIMA Yutaka

  Department of Food Science and Technology, Faculty of Agriculture, Kyushu University

• Osajima Y

  Kyushu Univ. Fukuoka Jpn

• Osajima Yutaka

  Department Of Bioresources And Biosciences Hiroshima Prefectural University

• Osajima Yutaka

  Kyushu Women's Univ.

• Matsui T

  Kyushu Univ. Fukuoka Jpn

• Matsui Toshiro

  Fac. Of Agriculture Graduate School Of Kyushu Univ.

• Matsui Toshiro

  Department Of Electrical And Electronic Engineering Tokyo Institute Of Technology

• Matsui Toshiro

  Department Of Applied Chemistry Faculty Of Engineering Doshisha University

• Kawasaki T

  Industrial Technol. Center Of Nagasaki

• Kawasaki Terukazu

  Kyushu-Sangyo University

• OSAJIMA Katsuhiro

  Senmi Ekisu Co.

• Kawasaki Terukazu

  The Second Dertment Of Internal Medicine

• Kawasaki Terukazu

  Institute Of Health Science Kyusyu University

• Osajima Y

  Kyushu Women's College

• Kawasaki T

  Institute Of Health Science Kyushu University : (present) H.s Division Of Endocrine And Diabetic Med

• Toshiro Matsui

  Faculty Of Agriculture Graduate School Kyushu University

• MATSUFUJI Hiroshi

  Department of Food Science and Technology, College of Bioresource Sciences, Nihon University (NUBS)

• MATSUFUJI Hiroshi

  Faculty of Agriculture, Kyushu University

• OSAJIMA Katsuhiro

  Research Laboratories, Senmi Ekisu Co.

• Ohshige Satoko

  Department of Food Science and Technology, Faculty of Agriculture, Kyushu University

• Kawasaki Terukazu

  Institute Of Health Science Kyuhu University

• Tanaka Kazunari

  Graduate School Of Human Health Science University Of Nagasaki

• Matsufuji Hiroshi

  Faculty Of Agriculture Kyushu University

• Matsufuji Hiroshi

  Department Of Food Bioscience And Biotechnology College Of Bioresource Sciences Nihon University

• Osajima Katsuhiro

  Research And Development Department Senmi Ekisu Co. Ltd.

• Ohshige Satoko

  Department Of Food Science And Technology Faculty Of Agriculture Kyushu University

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