The Renin-Angiotensin-Aldosterone System and Circadian Rhythm of Urine Variables in Normotensive and Hypertensive Subjects : SYMPOSIUM ON BLOOD PRESSURE AND VASOACTIVE SUBSTANCES

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概要

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• Forty-two middle-age male subjects, aged from 47 to 54 years old, were divided into three groups; 14 normotensives (NT), 16 borderline hypertensives (BHT) and 12 hypertensives (HT). The environmental effects were neutralized as much as possible by keeping their activities synchronized and their plasma and urine variables simultaneously investigated using the same protocol as under normal physiologic conditions. The circadian rhythms of urinary excretions of Na, K, Cl, creatinine, aldosterone, adrenaline and noradrenaline were analyzed by a multivariate method (cosinor method). Both systolic and diastolic blood pressure were statistically significantly different among the three groups and body weight was greater in HT than in NT. Other plasma and urine variables examined, however, were not significantly different among the three groups. A statistically significant circadian rhythm was detected in the urine variables. The rhythm characteristics, such as the mesor, amplitude and acrophase, of the urine variables except for the acrophase of urinary Na excretion were not significantly different among the three groups; the circadian acrophase of urinary Na in HT and BHT appeared significantly earlier than in NT. The pathophysiological and clinical significance of the earlier appearance of the circadian acrophase of urinary Na in hypertensive subjects still remains a unique characteristic requiring further investigation.

• 社団法人日本循環器学会の論文
• 1984-02-20

著者

• FUKIYAMA Koshiro

  University of the Ryukyus

• Uezono Keiko

  The Second Department Of Internal Medicine. Faculty Of Medicine Kyushu University. Fukuoka Japan

• Abe Isao

  Japan Seamen's Relief Association Moji Hospital

• Fukiyama Koshiro

  琉球大学医学部附属病院 血液浄化療法部

• Fukiyama K

  Univ. Ryukyus Okinawa Jpn

• Omae Teruo

  琉球大学 第3内科

• Ornae Teruo

  Second Dept. Of Intern. Med. Kyushu Univ. School Of Med.

• Oyama Tomomi

  千葉大学 循環病態医科学

• Uezono K

  Institute Of Health Science Kyushu University

• Omae T

  National Cardiovascular Center

• Omae Teruo

  2nd Div. Dept. Of Intern. Med. (prof. S. Katsuki) Facul. Of Med. Kyushu University Fukuoka

• Omae Teruo

  Second Department Of Internal Medicine Faculaty Of Medicine Kyushu University

• Ueno Michio

  Kyushu Medical Center Fukuoka

• Ueno Michio

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Abe Isao

  Second Department of Internal Medicine, Faculty of Medicine, Faculty of Medicine, Kyushu University

• KAWASAKI TERUKAZU

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• UEZONO KEIKO

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• KAWANO YUHEI

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• KAWAZOE NOBUYUKI

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• ETO TANENAO

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• FUKIYAMA KOSHIRO

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• Fukiyama Kohshiro

  Japan Seaman's Relief Association Moji Hospital

• Fukiyama Koshiro

  Second Department Of Internal Medicine Faculaty Of Medicine Kyushu University

• Kawasaki T

  Industrial Technol. Center Of Nagasaki

• Kawasaki Terukazu

  Kyushu-Sangyo University

• Kawasaki Terukazu

  The Second Dertment Of Internal Medicine

• Kawasaki Terukazu

  Institute Of Health Science Kyusyu University

• Kawasaki Terukazu

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Abe Isao

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Abe Isao

  Second Department Of Internal Medicine Faculty Of Medicine

• Abe Isao

  Medicine And Clinical Science. Graduate School Of Medical Sciences Kyushu University

• Kawasaki T

  Institute Of Health Science Kyushu University : (present) H.s Division Of Endocrine And Diabetic Med

• Uezono Keiko

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• KAWAZOE Nobuyuki

  Third Department of Internal Medicine, University of Ryukyus

• Kawasaki Terukazu

  Institute Of Health Science Kyuhu University

• Tanaka Kazunari

  Graduate School Of Human Health Science University Of Nagasaki

• Ohya Tetsuo

  2nd Dept. Of Internal Medicine Fac. Of Medicine Univ. Of Tokyo

• Kawazoe Nobuyuki

  Third Department Of Internal Medicine University Of Ryukyus

• Kawazoe Nobuyuki

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Abe Isao

  Department Of Medicine And Clinical Science Graduate School Of Medical Science Kyushu University

• OMAE Teruo

  Second Department of Internal Mecicine, Faculty of Medicine, Kyushu University

• KAWASAKI Terukazu

  Second Department of Internal Mecicine, Faculty of Medicine, Kyushu University

• FUKIYAMA Koshiro

  Second Department of Internal Mecicine, Faculty of Medicine, Kyushu University

• ETO Tanenao

  Second Department of Internal Medicine and Department of Anatomy, Faculty of Medicine, Kyushu University

• Omae Teruo

  Second Departemnt of Internal Medicine, Kyushu University

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