Influence of Unilateral Adrenalectomy on Renin-Angiotensin-Aldosterone System in Primary Aldosteronism

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概要

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• In a study of 14 patients (11 Japanese and 3 white North Americans) with aldosterone-producing tumor carried out within 2 to 4 weeks after unilateral adrenalectomy, both plasma renin activity (PRA) and plasma aldosterone concentration (PAC) increased almost normally with short-term sodium depletion and upright posture. Aldosterone excretion rate (AER) also increased significantly with sodium depletion, and was normally suppressed by sodium loading. Highly significant correlations were observed between PRA and PAC (r=0.89, p<0.001) or AER (r=0.88, p<0.001) ater operation, whereas there had been no such correlation before operation. Either physiological or laboratory findings were normalized or markedly improved in all cases although pathohistological diagnosis was made as adenomatous hyperplasia in 10 out of 11. These results indicate that within 4 weeks of operation PRA and the remaining adrenal gland can almost normally respond to stimuli such as sodium depletion and upright posture regardless of the amount of spironolactone given preoperatively.

• International Heart Journal刊行会の論文

著者

• Omae Teruo

  Second Department Of Internal Medicine Faculaty Of Medicine Kyushu University

• Ueno Michio

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• UEZONO KEIKO

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• KAWANO YUHEI

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• Fukiyama Koshiro

  Second Department Of Internal Medicine Faculaty Of Medicine Kyushu University

• Kawasaki Terukazu

  The Second Dertment Of Internal Medicine

• Kawasaki Terukazu

  Institute Of Health Science Kyusyu University

• Kawasaki Terukazu

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Uezono Keiko

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Noda Yasuhiro

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• KUMAMOTO KENSHI

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• Kawasaki Terukazu

  Institute Of Health Science Kyuhu University

• Tanaka Kazunari

  Graduate School Of Human Health Science University Of Nagasaki

• OGATA Masahiro

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• BARTTER Frederic

  ACOS for Research, the Audie Murphy Memorial Veterans Administration Hospital, Department of Medicin

• OMAE Teruo

  Second Department of Internal Mecicine, Faculty of Medicine, Kyushu University

• NODA Yasuhiro

  Second Department of Internal Mecicine, Faculty of Medicine, Kyushu University

• Ueno Michio

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• BARTTER Frederic

  ACOS for Research, the Audie Murphy Memorial Veterans Administration Hospital, Department of Medicine, University of Texas Health Science Center

• KAWASAKI Terukazu

  Second Department of Internal Mecicine, Faculty of Medicine, Kyushu University

• FUKIYAMA Koshiro

  Second Department of Internal Mecicine, Faculty of Medicine, Kyushu University

• KUMAMOTO Kenshi

  Second Department of Internal Mecicine, Faculty of Medicine, Kyushu University

• Ogata Masahiro

  Second Departemnt of Internal Medicine, Kyushu University

• Omae Teruo

  Second Departemnt of Internal Medicine, Kyushu University

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