Slowered Turnover of Norepinephrine in the Brain Associated with an Acute Elevation in Blood Pressure of Rats

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概要

• 論文の詳細を見る

• Acute responses of blood pressure and turnover of norepinephrine in the brain to intracisternally injected guanethidine were studied in rats. Systolic blood pressure in guanethidine-treated rats showed a dose-relating rise for over 9 hrs, while norepinephrine contents in cortex-cerebellum, brain stem and heart were not affected.The endogenous norepinephrine in brain samples, however, did not decrease against a-methyl-p-tyrosine to result in regression coefficients significantly different from those in the saline-treated group whereas norepinephrine in heart was reduced similarly in the 2 groups, indicating a slowered turnover of norepinephrine selectively in the brain. The results may indicate that the retarded norepinephrine turnover in the brain is causatively related with an acute elevation in blood pressure.

• International Heart Journal刊行会の論文

著者

• Omae T

  National Cardiovascular Center

• Omae Teruo

  Second Department Of Internal Medicine Faculaty Of Medicine Kyushu University

• Ito Akira

  Second Dept. Of Intern. Med. Facully Of Med. Kyushu Univ.

• Ito Akira

  Department Of Biochemistry And Molecular Biology School Of Pharmacy Tokyo University Of Pharmacy And

• Tanaka Kenjiro

  1st Department Of Internal Medicine Medical College Of Miyazaki

• Tanaka Kenjiro

  Department Of Applied Physics And Chemistry The University Of Electro-communications

• OMAE Teruo

  Second Department of Internal Mecicine, Faculty of Medicine, Kyushu University

• TANAKA Kenjiro

  Department of Internal Medicine, Miyazaki Medical College

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