Plasma Dopamine-β-Hydroxylase Activity in Normal Young Men : Its Responsiveness to Manipulation of Sodium Balance and Upright Posture
スポンサーリンク
概要
- 論文の詳細を見る
Plasma dopamine-β-hydroxylase (DBH) activity was examined in nine healthy young adults. DBH activity at rest had a wide range, near 0 to 44 I.U./L. When sodium depletion was performed by dietary sodium restriction and diuretic, the activity was significantly increased. With dietary sodium loading, it was decreased. The change in DBH activity was significantly correlated with that in hematocrit. When subjects were erected, the enzyme activity was elevated in situations regardless of sodium balance. Blood pressure and pulse rate were changed by manipulation of sodium balance and postural change. However, the change in DBH activity did not correlate with them. Plasma renin activity (PRA) was determined concomitantly in the same plasma with DBH. The change in PRA had a direct correlation with that in DBH activity. Furthermore, the change in mean arterial presure induced by infusion of angiotensin II analogue seemed to correlate with DBH activity change by sodium depletion. When the values of DBH activity in each individual were compared throughout the study, it was observed that the biggest variance in the activity of each individual was significantly correlated with the basal activity. In longitudinal study of individuals, plasma DBH activity could be a usuful index for estimation of sympathetic activity.
- 社団法人日本循環器学会の論文
- 1977-09-20
著者
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FUKIYAMA Koshiro
University of the Ryukyus
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Fukiyama Koshiro
琉球大学医学部附属病院 血液浄化療法部
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Fukiyama K
Univ. Ryukyus Okinawa Jpn
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Ornae Teruo
Second Dept. Of Intern. Med. Kyushu Univ. School Of Med.
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Omae T
National Cardiovascular Center
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Omae Teruo
2nd Dept-. Of Intern.med. Faculty Of Med. Kyusyu Univ
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Omae Teruo
2nd Div. Dept. Of Intern. Med. (prof. S. Katsuki) Facul. Of Med. Kyushu University Fukuoka
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Fukiyama Kohshiro
Japan Seaman's Relief Association Moji Hospital
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Fukiyama Koshiro
2nd Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Kawasaki Terukazu
The Second Dertment Of Internal Medicine
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Kawasaki Terukazu
Institute Of Health Science Kyusyu University
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Kawasaki T
Institute Of Health Science Kyushu University : (present) H.s Division Of Endocrine And Diabetic Med
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Noda Yasuhiro
Second Department Of Internal Medicine Faculty Of Medicine Kyushu University
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TAKISHITA SHUICHI
2nd Department oflnternal Medicine, Faculty ofMedicine, Kyushu University
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KUMAMOTO KENSHI
2nd Department oflnternal Medicine, Faculty ofMedicine, Kyushu University
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NODA YASUHIRO
2nd Department oflnternal Medicine, Faculty ofMedicine, Kyushu University
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KAWASAKI TERUKAZU
2nd Department oflnternal Medicine, Faculty ofMedicine, Kyushu University
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Kumamoto Kenshi
Kyushu Central Hospital
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Kawasaki Terukazu
Institute Of Health Science Kyuhu University
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Tanaka Kazunari
Graduate School Of Human Health Science University Of Nagasaki
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