Blood Pressure and Sympathetic Nervous Function in Spontaneously Hypertensive Rats Derived from Breeders on Low Sodium Diet : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
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概要
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We investigated the effect of dietary salt restriction in spontaneously hypertensive rat (SHR) breeders to determine if the development of hypertension of offspring would be blunted. Weaning SHRs (F-0) were divided into 3 groups and were given a diets containing sodium of 0.4% (G1), 0.05% (G2), or 0.4% plus mefruside 0.001% (G3) with distilled water. Potassium content was 0.75% and the other ingredients except chloride were identical in all the diets. Offsprings (F-1) were derived from selective inbreeding within each group. Systolic blood pressure rose over 160 mmHg by 8 weeks of age in all the male rats of all the groups in both F-0 and F-1. There was no difference in blood pressure between G 1 and G 2 at any age, while in G 3 blood pressure was significantly lower than in G 1 at 12 and 20 weeks of age in F-1. The findings in pressure were ascertained by heart-body weight ratio determined at autopsy, which was similar between G 1 and G 2, and was smaller in G 3 than the others at 20 weeks of age. Aldostrone excretion rate was markedly higher in G 2 than G 1 and G 3 at all study points, whereas plasma renin content was similar between G 1 and G 2, and higher in G 3. Plasma concentrations of noradrenaline and adrenaline did not differ among the 3 groups at any age in both F-0 and F-1. There was also no difference in cardiovascular responsiveness to intravenous noradenaline or hexamethonium among the groups at any age in both F-0 and F-1. It is concluded that life-long sodium restriction does not blunt the development of hypertension in SHR, which might be attributed to failure of suppression in sympathetic nervous function.
- 社団法人日本循環器学会の論文
- 1986-11-20
著者
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OMAE Teruo
National Cardiovascular Center
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FUKIYAMA Koshiro
University of the Ryukyus
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Fukiyama Koshiro
琉球大学医学部附属病院 血液浄化療法部
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Fukiyama K
Univ. Ryukyus Okinawa Jpn
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Omae Teruo
琉球大学 第3内科
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Ornae Teruo
Second Dept. Of Intern. Med. Kyushu Univ. School Of Med.
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FUKIYAMA Koshiro
Third Department of Internal Medicine, University of The Ryukyus
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Oyama Tomomi
千葉大学 循環病態医科学
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Omae T
National Cardiovascular Center
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Eto Tanenao
Third Department Of Internal Medfcine University Of The Ryukyus School Of Medicine
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Omae Teruo
2nd Div. Dept. Of Intern. Med. (prof. S. Katsuki) Facul. Of Med. Kyushu University Fukuoka
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KIMURA Yorio
Third Department of Internal Medicine, University of the Ryukyus School of Medicine
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Fukiyama Kohshiro
Japan Seaman's Relief Association Moji Hospital
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Fukiyama Koshiro
Third Department Of Internal Medicine University Of The Ryukyus School Of Medicine
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Tomita Yuji
Second Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Tomita Y
Kyushu Inst. Technology Kitakyushu Jpn
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TAKISHITA SHUICHI
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University
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Kimura Yorio
Third Department Of Internal Medicine University Of The Ryukyus School Of Medicine
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KAWAZOE Nobuyuki
Third Department of Internal Medicine, University of Ryukyus
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TSUMAGARI Tatsumi
Research Lab.. Yoshitomi Pharmac. Industries Ltd.,
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OHNISHI Kenichi
Seiwa Experimental Animals Ltd.
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Takishita Shuichi
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Ohya Tetsuo
2nd Dept. Of Internal Medicine Fac. Of Medicine Univ. Of Tokyo
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Kawazoe Nobuyuki
Third Department Of Internal Medicine University Of Ryukyus
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Tsumagari T
Research Lab.. Yoshitomi Pharmac. Industries Ltd.
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TAKISHITA Shuichi
Second Department of Internal Mecicine, Faculty of Medicine, Kyushu University
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