DETERMINATION OF UNINARY EXCRETIONS OF ALDOSTERONE AND SODIUM BY SHORT TERM COLLECTIONS OF URINE IN HEALTHY MEN

概要

論文の詳細を見る
The study was designed to evaluate the usefulness of urinary aldosterone and sodium excretions (AER and U_<Na>V) determined for 4- and 12-hour period in providing an accurate reflection of daily AER and U_<Na>V. Nine healthy young male volunteers were fed diets contained varying amount of sodium for a period of 4 days; 34 mEq/day as low-salt, 450 mEq/day as high-salt and 194 mEq/day as control diet. Urine collection was made every 4 hours starting at 8:00 a.m. for 24 hours on the last day of each period. The values for 12- and 24-hour urine were obtained by the sum of those for 4-hour collections. The values for both AER and U_<Na>V for every 4-hour showed remarkable circadian rhythms in any of 3 different dietary sodium intakes. The correlation between any 4-hour value for AER or U_<Na>V for and 24-hour value was highly significant (p < 0.001). The values for AER or U_<Na>V, expressed per gram creatinine excretion, also revealed highly significant correlation between any 4- or 12-hour and 24-hour period (p < 0.001). Highly significant correlations were also observed between thesupineplasma aldosterone concentration and the preceding 12-hour (p < 0.001) or 24-hour AER (p < 0.001). It can be concluded that AER and V_<Na>V measured in 4-hour or 12-hour period are a valid reflection of AER and U_<Na>V for 23 hours.
社団法人日本循環器学会の論文
1979-08-20