Increased Permeability of Arteriolar Wall Caused by Renal Extract in Nephrectomized Rats

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概要

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• Lysosomal fraction of high renin activity, obtained from renal cortex of normal rats by step-wise centrifugation method, phenylephrine and angiotensin II were injected into bilaterally nephrectomized rats. Blood pressure was raised 20mmHg for 60 min by the pressor agents. Ferritin was used to trace pathways of plasma protein insudation in the arterial wall. Animals infused with saline served as a control. Arterioles in the intestinal submucosa was observed by light and electron microscope. The arterial endothelium and the interendothelial cell junctions appeared to be intact in all the experimental animals. Ferritin was present in pinocytotic vesicles in the endothelial cells and in the subendothelial spaces, but never in the intercellular junctions in each of the experimental groups. Ferritin concentration in the subendothelial spaces, however, was the highest in lysosomal fraction group. Morphometric analysis concerning the vesicular transport, which appeared to be the main pathway of ferritin insudation, was performed in the arterial endothelium. Frequencies of the pinocytotic vesicles in the experimental groups resembled each other. Percentage of the pinocytotic vesicles labeled with ferritin, however, was significantly higher in lysosomal fraction group than that in the other groups. The results suggested that substance(s) contained in lysosomal fraction may exert direct action on the arterial endothelium and accelerate the labeling rate of pinocytotic vesicles with macromolecules, resulting in insudation of the plasma protein into subendothelial spaces of the arterioles.

• International Heart Journal刊行会の論文

著者

• Eto Tanenao

  The 2nd Depatment Of Internal Medicine And Department Of Anatomy Faculty Of Medicine Kyusyu Universi

• ONOYAMA Kaoru

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• Omae Teruo

  Second Department Of Internal Medicine Faculaty Of Medicine Kyushu University

• ETO TANENAO

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• Onoyama Kaoru

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• ONIKI Hideo

  Second Department of Internal Medicine and Department of Anatomy, Faculty of Medicine, Kyushu Univer

• YAMAMOTO Torao

  Second Department of Internal Medicine and Department of Anatomy, Faculty of Medicine, Kyushu Univer

• ONOYAMA Kaoru

  Second Department of Internal Medicine and Department of Anatomy, Faculty of Medicine, Kyushu University

• OMAE Teruo

  Second Department of Internal Medicine and Department of Anatomy, Faculty of Medicine, Kyushu University

• OMAE Teruo

  Second Department of Internal Mecicine, Faculty of Medicine, Kyushu University

• ONIKI Hideo

  Second Department of Internal Medicine and Department of Anatomy, Faculty of Medicine, Kyushu University

• YAMAMOTO Torao

  Second Department of Internal Medicine and Department of Anatomy, Faculty of Medicine, Kyushu University

• ETO Tanenao

  Second Department of Internal Medicine and Department of Anatomy, Faculty of Medicine, Kyushu University

• Omae Teruo

  Second Departemnt of Internal Medicine, Kyushu University

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