Perinephritis Hypertension in Monkeys : I. An Increase of Plasma Renin Activity Associated with Increased Permeability of Retinal Vessels and Angionecrosis

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The renal parenchyma of 5 crub-eating monkeys (Macaca irus) was wrapped by cellophane and plasma renin activity, blocd pressure and vascular permeability of ocular ground were measured in comparison with 5 unoperated control monkeys. The results demonstrated that increases of systolic arterial pressure, plasma renin activity, and permeability of the retinal vessels were found in 4 operated monkeys. There was no such abnormal finding in the unoperated control monkeys. Generally there was a rough parallelism among levels of plasma renin activity and systolic blood pressure, an increase of permeability of retinal vessels and fibrinoid angionecrosis and/or necrotizing angitis similar to polyarteritis nodosa.
International Heart Journal刊行会の論文