Prostanoids, Coronary Circulation and Coronary Artery Spasm in Open Chest Dogs and Miniature Pigs
スポンサーリンク
概要
- 論文の詳細を見る
Effects of prostanoids on coronary circulation were studied in anesthetized open chest dogs with intact coronary arteries or in closed chest Gottingen miniature pigs with denuded vessels. In the latter model, coronary artery spasm was repeatedly provoked at the previously denuded area by histamine i.c. after pretreatment with cimetidine i.v. H_2-blocker. In the canine model, prostacyclin (PGI_2) dilated to a greater extent the diameter of the large epicardial coronary artery than did PGE_2, and both equally reduced the total coronary resistance. Vasoconstrictive effects of carbocyclic thromboxane A_2, a stable analogue of thromboxane A_2 (TxA_2) on the epicardial coronary artery was augmented from 1.1±0.3 to 6.5±1.3% (p<0.01) after pretreatment with cyclooxygenase inhibitors. In case of Gottingen miniature pigs 3 months after endothelial denudation and cholesterol freeding, neither PGI_2 nor indomethacin prevented histamine-induced coronary artery spasm. Thiothromboxane A_2, a stable analogue of TxA_2, did not provoke coronary artery spasm in the animals. Therefore, prostanoids may not be crucial to the provocation or prevention of coronary artery spasm from which myocardial ischemia ensues.
- 社団法人日本循環器学会の論文
- 1987-04-20
著者
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Shimokawa Hiroaki
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Nakamura Motoomi
The Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Unive
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EGASHIRA KENSUKE
The Research Institute of Angiocardiology and Cardiovascular Clinic, Faculty of Medicine, Kyushu Uni
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SHIMOKAWA HIROAKI
The Research Institute of Angiocardiology and Cardiovascular Clinic, Faculty of Medicine, Kyushu Uni
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TOMOIKE HITONOBU
The Research Institute of Angiocardiology and Cardiovascular Clinic, Faculty of Medicine, Kyushu Uni
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Nakamura Motoomi
Reseach Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine
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Egashira Kensuke
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Med. Kyushu University
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Tomoike Hitonobu
The Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Unive
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Tomoike Hitonobu
Research Institute Of Angioeardiology And Cardiovascular Clinic Kyushu University
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Tomoike Hitonobu
Reserch Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu University
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Egashira Kensuke
The Research Institute Of Angiocardiology And Cardiovascular Clinic Kyushu University
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Tonoike Hitonobu
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Tomoike Hitonobu
Research Institute Of Angiocardiology And Cardiovascular Clinic Kyushu University Medical School
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Tomoike Hitonobu
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Tomoike Hitonobu
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Nakamura Motoomi
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Shimokawa Hiroaki
The Research Institute Of Angiocardiology And Cardiovascular Clinic Kyushu University School Of Medi
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Egashira Kensuke
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Tomoike Hitonobu
Research Institute Of Angiocaridology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Tomoike Hitonobu
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Nakamura Motoomi
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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