Quantitative Analysis of Regional Wall Motion in Dogs in Situ : Characteristics of End-Systolic Pressure-Length Relation : SYMPOSIUM ON MECHANICS OF CONTRACTION AND RELAXATION OF THE ISCHEMIC MYOCARDIUM : 50th Annual Scientific Session of Japanese Circula
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概要
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Regional wall motion was analyzed to deduce the muscle property unique to regional contractile states. End-systolic pressure length relations were evaluated 1) under global changes in a contractile state, 2) under selective intracoronary administration of inotropic agents to produce regional hypo- or hyper-kinesis, and 3) before and after extension of size of the ischemia. Linearity of thee end-systolic pressure-length relation was confirmed in each perturbation; however, the behavior of this relation with regard to changes in the slope and X-axis intercept differed among the three situations. When the contractile state was altered globally by intravenous administration of inotropic agents such as dobutamine and propranolol, the slope of the end-systolic pressure-length relation changed in a manner similar to that seen with the pressure-volume relation or stress-strain relation, with no significant changes in the X-axis intercept. Namely, the level of global cardiac function determined the slope of the end-systolic pressure length relation. When regional hypokinesis was produced pharmacologically by selective intracoronary infusion of lidocaine, the X-axis intercept moved rightward, depending on the degree of regional hypokinesis. Expansion in the size of the ischemic area also shifted the X-axis intercept rightward. The latter two phenomena suggested that the hypokinetic segments were stretched by the surrounding intact myocardium. Accordingly, end-systolic pressure-length relations provide useful information concerning the functional state of regional myocardium. The systolic properties of the regional myocardium rendered hypokinetic have to be quantified so as to include the total geometry of the heart.
- 社団法人日本循環器学会の論文
- 1987-01-20
著者
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UEHARA Yoshio
University of Tokyo
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Uehara Yoshio
Second Department Of Medicine University Of Tokyo
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Tomoike H
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Nakamura Motoomi
The Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Unive
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Urabe Yoshitoshi
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Nakamura Motoomi
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Nakamura Motoomi
Research Institute Of Angiocardiology And Cardiovascular Clinic And Information Science Laboratory F
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TOMOIKE HITONOBU
Reserch Institute of Angiocardiology and Cardiovascular Clinic, Faculty of Medicine, Kyushu Universi
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KASEDA SHUNICHI
Reserch Institute of Angiocardiology and Cardiovascular Clinic, Faculty of Medicine, Kyushu Universi
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URABE YOSHITOSHI
Reserch Institute of Angiocardiology and Cardiovascular Clinic, Faculty of Medicine, Kyushu Universi
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NAKAMURA MOTOOMI
Reserch Institute of Angiocardiology and Cardiovascular Clinic, Faculty of Medicine, Kyushu Universi
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Tomoike Hitonobu
The Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Unive
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Tomoike Hitonobu
Research Institute Of Angioeardiology And Cardiovascular Clinic Kyushu University
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Tomoike Hitonobu
Reserch Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu University
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Tonoike Hitonobu
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Kaseda Shunichi
Reserch Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu University
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Tomoike Hitonobu
Research Institute Of Angiocardiology And Cardiovascular Clinic Kyushu University Medical School
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Tomoike Hitonobu
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Tomoike Hitonobu
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Nakamura Motoomi
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Nakamura Motoomi
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Tomoike Hitonobu
Research Institute Of Angiocaridology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Urabe Yoshitoshi
Reserch Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu University
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Tomoike Hitonobu
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Uehara Yoshio
The Second Department Of Medicine University Of Tokyo
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NAKAMURA Motoomi
Reserch Instit, of Angiocardiology, Kyushu University Med. Sch., FUKUOKA
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