ALTERED PHOSPHOLIPASE C ACTIVITY IN RENAL MEDULLA OF DOCA-SALT HYPERTENSIVE RATS

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概要

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• We investigated the alterations of phospholipase C activity in the kidney and arterial wall of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Neither DOCA nor salt administration alone affected phospholipase C activity in the kidney and arterial wall. In contrast, when the rats were given both DOCA and salt and developed high blood pressure, the phospholipase C activity became greater in the outer and inner medulla (papilla) while the enzyme activity was reduced significantly in the renal cortex and arterial wall. Such an increase in phospholipase C activity was not observed in the kidney of a genetic rat for spontaneous hypertension. Moreover. the phospholipase A_2 activity was also stimulated in the renal medulla of DOCA-salt hypertensive rats. Thus. these data indicate that DOCA-salt hypertension is associated with an increase in phospholipase C activity in the renal medulla, which seems primary to the development of DOCA-salt hypertension.

• 社団法人日本循環器学会の論文
• 1991-05-20

著者

• HIRAWA Nobuhito

  Yokohama City University

• UEHARA Yoshio

  University of Tokyo

• HIRAWA Nobuhito

  Department of Internal Medicine and Cardiorenal Medicine Yokohama City University Graduate School of

• SAKAMOTO Tsuguya

  The Second Department of Internal Medicine

• Hirawa Nobuhito

  日本大学 医学部内科学系腎臓高血圧内分泌内科

• Hrawa Nobuhito

  Asahi Hospital

• Hirawa Nobuhito

  Division Of Cardiology Yamada Red Cross Hospital

• Hirawa Nobuhito

  Department Of Medical Science And Cardiorenal Medicine Yokohama City University Graduate School Of M

• Hirawa Nobuhito

  横浜市立大学 第2内科

• Hirawa Nobuhito

  Department Of Medicine Ii Yokohama City University School Of Medicine

• NUMABE Atsushi

  Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School o

• Uehara Yoshio

  Second Department Of Medicine University Of Tokyo

• Numabe Atsushi

  Department Of Clinical Laboratory Medicine And Institute Of Medical Science Dokkyo University School

• MATSUOKA Hiroaki

  The 2nd Dept.of Intern.Med.,Univ.of Tokyo.

• Yagi Shigeru

  The 2nd Dept. of Intern.Med., Univ. of Tokyo

• Sugimoto T

  The Second Department Of Internal Medicine

• Sugirnoto Tokuichiro

  Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of

• Sugimoto Tsuneaki

  Second Department Of Internal Medicine University Of Tokyo

• Sakamoto Tsuguya

  The 2nd Department Of Internal Medicine University Of Tokyo

• TAKADA Satoru

  Department of Internal Medicine, Saiseikai Maebashi Hospital

• UEHARA YOSHIO

  The 2nd Department of Medicine, University of Tokyo

• HIRAWA NOBUHITO

  The 2nd Department of Medicine, Yokohama City University

• IKEDA TOSHIO

  Department of Nephrology, Kantou-Teishin Hospital

• SUGIMOTO TSUNEAKI

  Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School o

• Urabe Yoshitoshi

  Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit

• Nishikawa Hideo

  Yamada Red Cross Hospital

• Sugimoto Tsuneaki

  Department Of Medicine Faculty Of Medicine University Of Tokyo

• Sugimoto Tokuichiro

  The Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Ikeda Toshio

  Depertment Of Nephrology Kantouteishin Hospital

• Yagi Shigeru

  The 2nd Dept. Of Intern.med. Univ. Of Tokyo

• Takada Satoru

  Department Of Architecture And Environmental Design Kyoto University

• Sugimoto Tsuneaki

  The 2nd Dept Of Internal Medicine University Of Tokyo

• Sugimoto Tsuneaki

  The 2nd Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Ikeda Toshio

  University Of Tokyo Second Dept. Of Internal Medicine

• Yagi Shigeru

  The 2nd Department Of Medicine University Of Tokyo

• Ikeda Toshio

  Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University

• Sugimoto Tsuneaki

  Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of

• Sakamoto Tsuguya

  The Second Dept. Of Internal Medicine Faculty Of Medicine Univ. Of Tokyo

• Sugirnoto Tokuichiro

  The 2nd Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Sugimoto Tsuneaki

  The 2nd Department Of Internal Medicine University Of Tokyo

• Sugimoto T

  The 2nd Dept Of Internal Medicine University Of Tokyo

• Ikeda Toshio

  Department Of Electronic Engineering Faculty Of Engineering Tohoku University

• Sakamoto Tsuguya

  The Second Department Of Internal Medicine Faculty Of Medicine. University Of Tokyo

• Sato Toshiaki

  Cardio-pulmonary Division Department Of Medicine Keio University School Of Medicine

• Ikeda Toshio

  Department Of Chemistry Faculty Of Science Shizuoka University

• Ikeda Toshio

  Department Electronic Engineering Faculty Of Engineering Tohoku University

• Hirawa Nobuhito

  Department Of Hemodialysis And Apheresis Division Of Nephrology And Hypertension Yokohama City University Medical Center Yokohama City University School Of Medicine

• Uehara Yoshio

  The Second Department Of Medicine University Of Tokyo

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