Role of Nitric Oxide in Regulation of Coronary Blood Flow in Response to Increased Metabolic Demand in Dogs With Pacing-Induced Heart Failure
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概要
- 論文の詳細を見る
The role of endothelium-derived nitric oxide(NO)in the metabolic control of coronary blood flow(CBF)in heart failure(HF)is poorly understood, so the present study investigated the effects of inhibitors of NO synthesis on the response of CBF to changes in myocardial oxygen consumption(MVO_2)in dogs with HF produced by rapid ventricular pacing and in control dogs. The CBF, MVO_2, and other hemodynamic parameters were measured in anesthetized animals. Before infusion of N^ω-nitro-L-arginine methyl ester(L-NAME), the increases in CBF and MVO_2 during pacing tachycardia were not significantly different between the control and HF dogs. Intracoronary infusion of L-NAME did not alter the responses of CBF or MVO_2 to pacing tachycardia in the control dogs, but in the HF dogs, it reduced the CBF response to pacing tachycardia without altering the tachycardia-induced changes in MVO_2. Intracoronary infusion of L-arginine reversed the effect of L-NAME. These results suggest that in HF dogs NO contributes to the regulation of CBF in response to an increased metabolic demand.
- 社団法人日本循環器学会の論文
- 2001-08-20
著者
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Takeshita Akira
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Shimokawa Hiroaki
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Egashira Kensuke
Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University
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Arai Yukinori
Research Institute Of Angiocardiology And Cardiovascular Clinic Kyushu University School Of Medicine
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Egashira Kensuke
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Med. Kyushu University
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Katsuda Yousuke
Research Institute of Cardiovascular Disease, Kurume University School of medicine
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Katsuda Yousuke
Research Institute Of Angiocardiology And Cardiovascular Clinic Kyushu University School Of Medicine
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Tada Hideo
Research Institute Of Angiocardiology And Cardiovascular Clinic Kyushu University School Of Medicine
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Usui Makoto
Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University
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Yamamoto Mitsutaka
Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University School of Medicin
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Usui Makoto
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kyushu University
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Yamamoto Mitsutaka
Research Institute Of Angiocardiology And Cardiovascular Clinic Kyushu University School Of Medicine
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Takeshita Akira
Research Institute Of A Ngiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universi
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Egashira Kensuke
Research Institute of Angiocardiology and Cardiovascular Clinic , Faculty of Med. Kyushu University
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