Effects of Dietary Oyster Extract on Lipid Metabolism, Blood Pressure, and Blood Glucose in SD Rats, Hypertensive Rats, and Diabetic Rats

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概要

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• Oyster extract was prepared by hydrolysis of oyster protein with proteases, Aloase (a protease from Bacillus subtilis), and Pancitase (a protease from Aspergillus oryzae). Rats were fed a diet containing 20% casein (the control diet) or 15% casein and 5% oyster extract (the oyster extract diet) as the protein source. The oyster extract diet exerted a significant reduction in serum cholesterol and liver triglyceride concentrations as compared with the control diet in Sprague-Dawley (SD) rats fed cholesterol-supplemented diets for 4 weeks. The activities of cytosolic fatty acid synthase and glucose-6-phosphate dehydrogenase were significantly lower in the oyster extract group than in the control group in the liver of SD rats. Hepatic cholesterol and triglyceride concentrations were significantly lower in spontaneously hypertensive (SH) rats and Otsuka Long-Evans Tokushima Fatty (OLETF) rats, type 2 diabetic rats, fed the oyster extract diet, for 4 weeks and 4 months respectively, than in those fed the control diet in the cholesterol-free diet. Blood pressure was significantly lower in the oyster extract group than in the control group at the 2nd and 4th weeks after the beginning of feeding experimental diets in SH rats. These results suggest that oyster extract prepared by hydrolysis of oyster induces triglyceride-lowering activity in the liver through a decrease in hepatic lipogenesis in SD rats, and that it exerts the antihypertensive effect in SH rats.

• 社団法人 日本農芸化学会の論文
• 2006-02-23

著者

• Ikeda Ikuo

  九州大学

• Tanaka K

  Institue Of Molecular And Cellular Biosciences The University Of Tokyo

• Ikeda Ikuo

  Graduate School Of Agricultural Sci. Tohoku Univ.

• Ikeda Ichiro

  Department Of Food Science And Technology Faculty Of Agriculture Kyushu University

• Tanaka K

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Tanaka K

  Tottori Univ. Tottori

• Nishizono Shoko

  Graduate School Of Human Health Science Siebold University Of Nagasaki

• TANAKA Kazunari

  Graduate School of Human Health Science, Siebold University of Nagasaki

• KUGINO Kenji

  Graduate School of Human Health Science, Siebold University of Nagasaki

• TAMARI Masato

  Faculty of Education, Graduate School Nagasaki University

• KURUMIYA Motoshi

  Tokiwa Yakuhin, Co., Ltd.

• ABE Naoyuki

  Tensei Suisan Co., Ltd.

• Tanaka Kan

  Laboratory Of Molecular Genetics Department Of Molecular Biology Institute Of Molecular And Cellular

• Kawasaki T

  Industrial Technol. Center Of Nagasaki

• Kawasaki Terukazu

  Kyushu-Sangyo University

• Ikeda Ikuo

  Laboratory Of Nutrition Chemistry Kyushu University School Of Agriculture

• Ikeda Ikuo

  Division Of Applied Biological Chemistry Department Of Bioscience And Biotechnology Faculty Of Agric

• Ikeda Ikuo

  Department Of Bioscience And Biotechnology Division Of Bioresource And Bioenvironmental Sciences Gra

• Kawasaki Terukazu

  Institute Of Health Science Kyusyu University

• Ikeda Ikuo

  東北大学 農学研究科生体分子機能学

• Kawasaki T

  Institute Of Health Science Kyushu University : (present) H.s Division Of Endocrine And Diabetic Med

• Abe Naoyuki

  Tensei Suisan Co. Ltd.

• Kugino Kenji

  Graduate School Of Human Health Science Siebold University Of Nagasaki

• Tamari Masato

  Faculty Of Education Graduate School Nagasaki University

• Nishida Satoko

  Laboratory Of Nutrition Chemistry Faculty Of Bioresources And Bioenvironmental Sciences Graduate Sch

• Ikeda Ikuo

  Laboratory Of Food And Biomolecular Science Department Of Food Function And Health Graduate School O

• Kawasaki Terukazu

  Institute Of Health Science Kyuhu University

• Nishida S

  Graduate School Of Human Health Science University Of Nagasaki

• Tanaka Kazunari

  Graduate School Of Human Health Science University Of Nagasaki

• Kurumiya Motoshi

  Tokiwa Yakuhin Co. Ltd.

• Tanaka Kazunari

  Graduate School Of Human Health Sci. Siebold Univ. Of Nagasaki

• Ikeda Ikuo

  Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University

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