Hypotensive Response to Angiotensin II Analogue and Angiotensin I Converting Enzyme Inhibitor in Pseudo-Bartters Syndrome

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概要

• 論文の詳細を見る

• We studied the effect of angiotensin II analogue (AII-A) and angiotensin I converting enzyme inhibitor (SQ 14, 225) on blood pressure and the renin-angiotensin-aldosterone system in a patient with pseudo-Bartters syndrome, who was a 26-year-old unmarried Japanese woman taking furosemide surreptitiously.The intravenous infusion of AII-A decreased blood pressure from 85/35 to 68/28mmHg. This decrease in blood pressure was associated with an increment of plasma renin activity (PRA) and a decrement of plasma aldosterone concentration (PAC). Similarly, SQ 14, 225 given orally decreased blood pressure to the same extent. An increment of PRA and a decrement of PAC were also observed.These results suggest that the renin-angiotensin system plays a considerable role in maintaining blood pressure in pseudo-Bartters syndrome. Again, attention has to be paid to the possibility of surreptitious use of diuretics in an adult patient with persistent hypokalemic alkalosis, hyperactivity of the renin-angiotensin-aldosterone system and angiotensin II insensitivity simulating "true" Bartters syndrome

• International Heart Journal刊行会の論文

著者

• ASANO Takashi

  First Department of Internal Medicine, School of Medicine, Fukuoka University

• Kawasaki Terukazu

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Okumura Makoto

  First Department Of Medicine Fukuoka University School Of Medicine

• SASAKI Haruka

  First Department of Internal Medicine, Fukuoka University, School of Medicine

• FUJISAWA Miwako

  First Department of Internal Medicine, Fukuoka University, School of Medicine

• MOTOOKA Yasushi

  First Department of Internal Medicine, Fukuoka University, School of Medicine

• Asano Takashi

  First Department Of Internal Medicine School Of Medicine Fukuoka University

• ASANO Takashi

  First Department of Internal Medicine, Fukuoka University, School of Medicine

• SASAKI HARUKA

  First Department of Internal Medicine, Fukuoka University

• KAWASAKI Terukazu

  Second Department of Internal Mecicine, Faculty of Medicine, Kyushu University

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