Durable Antihyperglycemic Effect of 6-O-Caffeoylsophorose with α-Glucosidase Inhibitory Activity in Rats
スポンサーリンク
概要
- 論文の詳細を見る
To evaluate the duration of antihyperglycemic effects of 6-O-caffeoylsophorose (CS), a newly identified natural α-glucosidase inhibitor from fermented purple-sweet potato, a single oral administration of CS was given to maltose-loaded Sprague-Dawley rats. Administration of CS (200 mg/kg) 30 min or 60 min before maltose administration produced an elevation of blood glucose level by administration of 2 g/kg of maltose in rats that was significantly lower than for no administration (control). In contrast, simultaneous or pro-administration of CS with maltose eliminated the antihyperglycemic effect. CS significantly reduced rat intestinal α-glucosidase activity in all of the small intestinal mucosal regions with a maximal reduction ratio of ca. 40% up to 60 min after CS administration. Thereafter, the intestinal α-glucosidase activity tended to return to basal level. These findings suggest that the antihyperglycemic effect of CS is restricted to pre-administration within 60 min.
- 社団法人 日本食品科学工学会の論文
- 2008-09-01
著者
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TERAHARA Norihiko
Department of Food Science for Health, Faculty of Health and Nutrition, Minami-Kyushu University
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OHTA Hideaki
Department of Developmental Medicine (Pediatrics), Osaka University Graduate School of Medicine
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MATSUMOTO Kiyoshi
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu Universi
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Matsumoto Ken-ichi
Dep. Of Biosignaling And Radioisotope Experiment Center For Integrated Res. In Sci. Shimane Univ.
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Matsumoto Ken-ichiro
Departments Of Physical Chemistry Showa Pharmaceutical University
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Matsui T
Kyushu Univ. Fukuoka Jpn
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Matsui Toshiro
Fac. Of Agriculture Graduate School Of Kyushu Univ.
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Matsui Toshiro
Department Of Electrical And Electronic Engineering Tokyo Institute Of Technology
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Matsui Toshiro
Department Of Applied Chemistry Faculty Of Engineering Doshisha University
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Fujise Tomoko
Nakamura Gakuen Univ. Fukuoka Jpn
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Matsumoto K
Graduate School Of Bioresource And Bioenvironmental Sciences Kyushu Univ.
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FUJISE Tomoko
Department of Bioscience and Biotechnology, Division of Bioresource and Bioenvironmental Sciences, F
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FUKUI Keiichi
Miyazaki JA Food Research & Development Inc.
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SUGITA Koichi
Miyazaki JA Food Research & Development Inc.
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Matsumoto K
Department Of Bioscience And Biotechnology Division Of Bioresource And Bioenvironmental Sciences Fac
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Fujise Tomoko
Department Of Bioscience And Biotechnology Division Of Bioresource And Bioenvironmental Sciences Fac
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Fukui Keiichi
Miyazaki Ja Food Research & Development Inc.
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Toshiro Matsui
Faculty Of Agriculture Graduate School Kyushu University
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MATSUMOTO Ken-ichi
Denartment of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Terahara N
Minami‐kyushu Univ. Miyazaki Jpn
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Terahara Norihiko
Department Of Food Science And Technology College Of Horticulture
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Matsumoto Kiyoshi
Department Of Applied Chemistry Faculty Of Engineering Kanagawa University
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