Increased Expression of Interleukin-1β in Mouse Hippocampus after Global Cerebral Ischemia
スポンサーリンク
概要
- 論文の詳細を見る
We examined the in vivo expression of IL-1β and its transcript after cerebral ischemia produced in mice cardiac arrest model. The IL-1β mRNA in the hippocampal region reached a detectable level at 1 hr after ischemia and had a peak at 3 hr after ischemia recirculation. But it was markedly decreased at 1 day and reached the control levels at 4 day after ischemia recirculation. The IL-1β-like immunoreactivity was observed at 1, 2, 4 day after ischemia recirculation and its immunoreactivity was detected at 2 day. The IL-1β-like immunoreactivity was observed in both microglia and astrocytes after bran ischemia by double immunostaining. These results provide the direct evidence for the localization and induction of IL-1β expression in vivo in mice after ischemia. It is suggested that IL-1β, produced in both astrocytes and microglia cells after ischemia, directly affect on neurons as well as glial cells to induce delayed neuronal cell death.
- 日本組織細胞化学会の論文
著者
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Asano M
Inst. Med. Sci. Tokyo Univ.
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Asano Masahide
昭和大学 薬学部
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土肥 謙二
昭和大学医学部救急医学
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土肥 謙二
昭和大学 脳神経外科
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OHTAKI Hirokazu
Department of First Anatomy, Showa University School of Medicine
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Shioda S
Department Of First Anatomy Showa University School Of Medicine
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Shioda Seiji
Department Of Anatomy Showa University School Of Medicine
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Shioda Seiji
昭和大学藤が丘病院 循環器内科
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Shioda Seiji
昭和大学 薬学部
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Ohtaki Hirokazu
Department Of First Anatomy Showa University School Of Medicine
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Ohtaki Hirokazu
昭和大学藤が丘病院 循環器内科
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Ohtaki Hirokazu
Department Of Anatomy Showa University School Of Medicine
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土肥 謙二
昭和大学 医学部第二病理学教室
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Ohtaki H
Department Of First Anatomy Showa University School Of Medicine
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MATSUMOTO Kiyoshi
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu Universi
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Matsumoto Hiroaki
Departments of Cardiology, Osaka Medical Center for Cancer and Cardiovascular Diseases
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Funahashi Hisayuki
Department of Anatomy, Showa University School of Medicine
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Shioda Seiji
Department Of Anatomy School Of Medicine Showa University
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DOHI Kenji
Department of Anatomy, Showa University School of Medicine
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Imaizumi Yoichi
Department of Neurosurgery, Showa University School of Medicine
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Mizushima Hidekatsu
Department of Neurosurgery, Showa University School of Medicine
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Matsunaga Seiji
Department of Anatomy, Showa University School of Medicine
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Horai Reiko
The University of Tokyo, The Institute of Medical Science, Laboratory of Animal Research Center
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Asano Masahide
The University of Tokyo, The Institute of Medical Science, Laboratory of Animal Research Center
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Iwakura Yoichiro
The University of Tokyo, The Institute of Medical Science, Laboratory of Animal Research Center
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Dohi K
Department Of Anatomy Showa University School Of Medicine
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Dohi Kenji
Department Of Anatomy Showa University School Of Medicine
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Funahashi Hisayuki
Department Of Anatomy Showa University School Of Medicine
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Funahashi Hisayuki
Department Of Anatomy School Of Medicine Showa University
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Matsumoto Hiroaki
Department Of Cardiology Osaka Medical Center For Cancer And Cardiovascular Diseases
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Horai Reiko
National Human Genome Research Institute National Institutes Of Health
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Horai Reiko
Center For Experimental Medicine Institute Of Medical Science University Of Tokyo
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Iwakura Yoichiro
東京大学医科学研究所 癌細胞シグナル分野
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Mizushima Hidekatsu
Department Of Neurosurgery Showa University School Of Medicine
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Mizushima Hidekatsu
Department Of Neurosurgery Shioda Hospital
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Matsunaga Seiji
Department Of Anatomy Showa University School Of Medicine
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Iwai Yasuhiro
Department Of Pathology Shiga University Of Medical Science
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Shioda Seiji
昭和大学 医学部第一解剖学教室
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Shiota Seiji
Department Of Anatomy Showa University School Of Medicine
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Ozawa Hiroshi
Department Of Neurosurgery Showa University School Of Medicine
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Matsushima K
Department Of Molecular Preventive Medicine & Sorst Graduate School Of Medicine University Of To
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Matsushima K
Univ. Tokyo Tokyo Jpn
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Ozawa Hiroshi
Department Of First Anatomy Showa University School Of Medicine
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Iwai Y
Center For Experimental Medicine Institute Of Medical Science University Of Tokyo
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Matsumoto Kiyoshi
Department Of Molecular Preventive Medicine School Of Medicine University Of Tokyo
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Matsumoto Kiyoshi
Department Of Applied Chemistry Faculty Of Engineering Kanagawa University
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Matsumoto Hiroaki
Department Of Neurosurgery Showa University School Of Medicine
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Mizushima Hidekatsu
塩田病院
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Matsumoto Hiroaki
Department Of Applied Chemistry Graduate School Of Engineering Osaka Prefecture University
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