Distribution and Neuronal Networks of Novel GPCR Ligands in Feeding Regulation(<SPECIAL ISSUE>Tokyo Satellite Symposium "Contribution of Histochemistry in Basic Science and Clinical Medicine")
スポンサーリンク
概要
- 論文の詳細を見る
Recent studies have shown that a number of novel G-protein coupled receptor (GPCR) ligands localize in brain tissue and perform a range of physiological functions, some of which have been studied and clarified, and others about which less is known. Here, we wish to describe the distribution and localization of GPCR ligands identified thus far and to examine their involvement in neuronal networks, particularly those networks related to feeding regulation. The review analyzes published reports of morphological and physiological data looking mainly at the functional significance of feeding-regulation factors, such as those described by our research group and others, and neuronal interactions among these GPCR ligands in the hypothalamus. Cross-talk among several GPCR ligand-containing neuron types in the hypothalamus plays a role in determining feeding states. We introduce structural and functional characteristics of novel GPCR ligands and summarize the known interactions between several GPCR ligand-containing neuron types and leptin-targeting neurons in the hypothalamus. Finally, we present a new scheme summarizing neuronal networks with regard to feeding regulation in the hypothalamus. Research in this area will play an important role in clarifying neurologically-based causes for appetite dysfunction and establishing therapies for people suffering from such conditions.
- 日本組織細胞化学会の論文
著者
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Shioda Seiji
Department Of Anatomy Showa University School Of Medicine
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Shioda S
Department Of Anatomy Showa University School Of Medicine
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KAGEYAMA Haruaki
Showa University School of Medicine
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SHIODA Seiji
Showa University School of Medicine
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Kageyama Haruaki
Department Of Molecular Toxicology And Coe Program In The 21st Century School Of Pharmaceutical Scie
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Takenoya Fumiko
Hoshi University School Of Pharmacy:showa University School Of Medicine
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Takenoya Fumiko
昭和大学 第1解剖学
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Shioda S
Showa University School Of Medicine
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TAKENOYA Fumiko
Department of Anatomy, Showa University School of Medicine
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Guan Jian
Department of Anatomy, Showa University School of Medicine
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Kita Tetsuro
Department of Anatomy, Showa University School of Medicine
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Funahashi Hisayuki
Department of Anatomy, Showa University School of Medicine
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Kitamura Yoshitaka
Department of Anatomy, Showa University School of Medicine
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Hirayama Masami
Department of Anatomy, Showa University School of Medicine
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Takeuchi Masao
Department of Physical Education, Hoshi University School of Pharmacy and Pharmacological Science
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Shioda Seiji
Department Of Anatomy School Of Medicine Showa University
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Funahashi Hisayuki
Department Of Anatomy Showa University School Of Medicine
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Funahashi Hisayuki
Department Of Anatomy School Of Medicine Showa University
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Hirayama Masami
Department Of Anatomy Showa University School Of Medicine
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Guan J‐l
Department Of Anatomy Showa University School Of Medicine
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Kita Tetsuro
Department Of Anatomy Showa University School Of Medicine
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Kitamura Yoshitaka
Department Of Anatomy Showa University School Of Medicine
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Guan Jian
Department Of Anatomy Showa University School Of Medicine
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Kageyama Haruaki
Department Of Anatomy Showa University School Of Medicine
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Takeuchi Masao
Department Of Electronic Engineering Tamagawa University
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Takeuchi Masao
Department Of Physical Education Hoshi University School Of Pharmacy And Pharmacological Science
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TAKEUCHI Masao
Department of Electrical and Electronic Engineering, Ibaraki University
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