Evaluation of Brain Ischemia in Mice
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概要
- 論文の詳細を見る
Cerebrovascular disease is the third leading cause of death in the industrialized world and is also a major cause of long-lasting disability. The development of gene deficient and transgenic mice has recently aided in research into and development of specific surgical procedures for brain ischemia in mice. The models of brain ischemia are divided into global ischemia and focal ischemia. Global ischemia is divided into two submodels, forebrain ischemia and total ischemia. Forebrain ischemia is widely used to analyze delayed neuronal cell death including apoptosis, while total ischemia is used to clarify the neuronal cell death by the systemic ischemia such as cardiac arrest. On the other hand, focal ischemia is used to analyze pathological stroke. Pathophysiology of brain ischemia has been clarified by the use of these models. This review outlines the pathways that lead to cell death following ischemia. Moreover, we have reviewed these currently-used mouse experimental models of global and focal ischemia.
- 日本組織細胞化学会の論文
著者
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土肥 謙二
昭和大学医学部救急医学
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土肥 謙二
昭和大学 脳神経外科
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OHTAKI Hirokazu
Department of First Anatomy, Showa University School of Medicine
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Shioda S
Department Of First Anatomy Showa University School Of Medicine
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Shioda Seiji
Department Of Anatomy Showa University School Of Medicine
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Shioda Seiji
昭和大学藤が丘病院 循環器内科
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Shioda Seiji
昭和大学 薬学部
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Ohtaki Hirokazu
Department Of First Anatomy Showa University School Of Medicine
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Ohtaki Hirokazu
昭和大学藤が丘病院 循環器内科
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Ohtaki Hirokazu
Department Of Anatomy Showa University School Of Medicine
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Yofu Sachiko
Department Of First Anatomy Showa University School Of Medicine
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Yofu Sachiko
昭和大学藤が丘病院 循環器内科
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Yofu Sachiko
Department Of Anatomy Showa University School Of Medicine
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Nakamachi Tomoya
Department Of First Anatomy Showa University School Of Medicine
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Nakamachi Tomoya
昭和大学藤が丘病院 循環器内科
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Nakamachi Tomoya
Department Of Anatomy Showa University School Of Medicine
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土肥 謙二
昭和大学 医学部第二病理学教室
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Ohtaki H
Department Of First Anatomy Showa University School Of Medicine
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Endo Satoru
Department Of Biochemistry Cancer Institute Okayama University Medical School
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Shioda Seiji
Department Of Anatomy School Of Medicine Showa University
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Dohi Kenji
Emergency and Clinical Care Medicine, Showa University School of Medicine
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Endo Sakura
Department of Anatomy, and Clinical Care Medicine, Showa University School of Medicine
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Kudo Yoshifumi
Department of Anatomy, and Clinical Care Medicine, Showa University School of Medicine
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Dohi K
Department Of Anatomy Showa University School Of Medicine
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Shioda Seiji
Laboratory Of Regulatory Biology Graduate School Of Science And Engineering University Of Toyama
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Endo Sakura
Department Of Anatomy And Clinical Care Medicine Showa University School Of Medicine
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Kudo Yoshifumi
Department Of Anatomy And Clinical Care Medicine Showa University School Of Medicine
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Shioda Seiji
昭和大学 医学部第一解剖学教室
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Shiota Seiji
Department Of Anatomy Showa University School Of Medicine
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Ozawa Hiroshi
Department Of Neurosurgery Showa University School Of Medicine
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Ozawa Hiroshi
Department Of First Anatomy Showa University School Of Medicine
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Shioda Seiji
Department Of Anatomy Showa University School Of Medicine Tokyo Japan
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