Cardioprotective Effect of Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide on Doxorubicin-Induced Cardiomyopathy in Mice

スポンサーリンク

概要

• 論文の詳細を見る

• Background: Pituitary adenylate cyclase-activating polypeptide (PACAP) is known as a cytoprotective polypeptide. PACAP and its receptors are expressed in the heart, but it is unclear whether PACAP exerts its protective effect on the myocardium in vivo. The aim of the present study was to investigate whether endogenous PACAP has a cardioprotective effect on Doxorubicin (Dox)-induced cardiomyopathy. Methods and Results: Dox was intraperitoneally injected to induce cardiomyopathy in wild type (WT) and PACAP knockout (ie, PACAP+/- and PACAP-/-) mice. The survival rates up to 15 days of PACAP+/- mice and PACAP-/- mice were significantly less than that of WT mice. Cardiac function, measured by echocardiography, was significantly lower in PACAP+/- mice than in WT mice at day 10. Morphological examination of sections of myocardium showed degenerative change and fibrosis in PACAP+/- mice at day 10. Serum reactive oxygen metabolites (a marker of oxidative stress), the number of 8-hydroxy-deoxyguanosine-positive nuclei and TdT-mediated dUTP nick end-labeling (TUNEL) positive nuclei in the myocardium were higher in PACAP+/- mice than WT mice. However, continuous subcutaneous administration of PACAP38 was able to prevent the myocardial damage typically caused by Dox injection in PACAP+/-. Conclusions: These results suggest that endogenous PACAP might attenuate Dox-induced myocardial damage and that its mechanism of action is likely to be associated with the reduction of oxidative stress and mediated via anti-apoptotic effects.

• 2010-05-25

著者

• Suzuki H

  Third Department Of Internal Medicine Showa University School Of Medicine

• SATO Atsushi

  Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate Scho

• TAKEYAMA Youichi

  Division of Cardiology, Showa University Fujigaoka Hospital

• Suzuki Hiroshi

  Division of Cardiology, Department of Internal Medicine, Showa University Fujigaoka Hospital

• MORI Hiroyoshi

  Division of Cardiology, Department of Internal Medicine, Showa University Fujigaoka Hospital

• NAKAMACHI Tomoya

  Department of First Anatomy, Showa University School of Medicine

• OHTAKI Hirokazu

  Department of First Anatomy, Showa University School of Medicine

• YOFU Sachiko

  Department of First Anatomy, Showa University School of Medicine

• ENDO Kimi

  Department of First Anatomy, Showa University School of Medicine

• ISO Yoshitaka

  Division of Cardiology, Department of Internal Medicine, Showa University Fujigaoka Hospital

• SHINTANI Norihito

  Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka Univers

• HASHIMOTO Hitoshi

  Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka Univers

• BABA Akemichi

  Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka Univers

• SHIODA Seiji

  Department of First Anatomy, Showa University School of Medicine

• Takeyama Y

  Division Of Cardiology Department Of Internal Medicine Showa University Fujigaoka Hospital

• Shioda S

  Department Of First Anatomy Showa University School Of Medicine

• Shioda Seiji

  Department Of Anatomy Showa University School Of Medicine

• Shioda Seiji

  昭和大学藤が丘病院 循環器内科

• Shioda Seiji

  昭和大学 薬学部

• Ohtaki Hirokazu

  Department Of First Anatomy Showa University School Of Medicine

• Ohtaki Hirokazu

  昭和大学藤が丘病院 循環器内科

• Ohtaki Hirokazu

  Department Of Anatomy Showa University School Of Medicine

• Yofu Sachiko

  Department Of First Anatomy Showa University School Of Medicine

• Yofu Sachiko

  昭和大学藤が丘病院 循環器内科

• Yofu Sachiko

  Department Of Anatomy Showa University School Of Medicine

• Shintani Norihito

  Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit

• Shintani Norihito

  昭和大学藤が丘病院 循環器内科

• Nakamachi Tomoya

  Department Of First Anatomy Showa University School Of Medicine

• Nakamachi Tomoya

  昭和大学藤が丘病院 循環器内科

• Nakamachi Tomoya

  Department Of Anatomy Showa University School Of Medicine

• Endo Kimi

  Department Of First Anatomy Showa University School Of Medicine

• Baba Akemichi

  Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit

• Baba Akemichi

  昭和大学藤が丘病院 循環器内科

• Iso Yoshitaka

  Division Of Cardiology Department Of Internal Medicine Showa University Fujigaoka Hospital

• Takeyama Youichi

  Division Of Cardiology Department Of Internal Medicine Showa University Fujigaoka Hospital

• Takeyama Youichi

  昭和大学藤が丘病院 循環器内科

• Baba Akemichi

  サントリー生物医学研究所

• Ohtaki H

  Department Of First Anatomy Showa University School Of Medicine

• Shioda Seiji

  Department Of Anatomy School Of Medicine Showa University

• Mori Hiroyoshi

  Division Of Cardiology Department Of Internal Medicine Showa University Fujigaoka Hospital

• Sawada Hitoshi

  Department Of Cardiovascular Surgery Cardiology The Cardiovascular Institute

• Shioda Seiji

  Laboratory Of Regulatory Biology Graduate School Of Science And Engineering University Of Toyama

• Hashimoto Hitoshi

  Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit

• Shioda Seiji

  昭和大学 医学部第一解剖学教室

• Suzuki Hiroshi

  Third Department Of Internal Medicine Showa University School Of Medicine

• Shiota Seiji

  Department Of Anatomy Showa University School Of Medicine

• Sakamoto Hiroshi

  Division Of Cardiology Department Of Internal Medicine Showa University Fujigaoka Hospital

• Baba Akemichi

  Laboratory Of Molecular Neuropharmacology

• Takeyama Youichi

  The Third Department Of Internal Medicine

• Suzuki Hiroshi

  昭和大学 医学部内科学講座循環器内科学

• Suzuki Hiroshi

  Division Of Cardiology Department Of Internal Medicine Showa University Fujigaoka Hospital

• Ozawa Hiroshi

  Department Of First Anatomy Showa University School Of Medicine

• Suzuki Hiroshi

  Department Of Cardiology Saitama Prefecture Cardiovascular Respiratory Center

• Sato Atsushi

  Department Of Applied Chemistry Chubu University

• Baba Akemichi

  Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit

• Ito Yasuki

  Third Department Of Internal Medicine Showa University School Of Medicine

• Shioda Seiji

  Department Of Anatomy Showa University School Of Medicine Tokyo Japan

関連論文

• Recruitment of Immune Cells Across Atrial Endocardium in Human Atrial Fibrillation
• The association between masked hypertension and waist circumference as an obesity-related anthropometric index for metabolic syndrome : the Ohasama study
• PJ-751 Impact of Smoking on Restenosis after Percutaneous Coronary Intervention (PCI) with Bare Metal Stents (BMS)(PJ126,Smoking/Alcohol/Life Style (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-479 Additional Evaluation for Ischemia is Required to Perform CAG after MSCT(PJ081,CT/MRI (Coronary/Vascular) 3 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Inhibitory Effect of Valsartan Against Progression of Left Ventricular Dysfunction After Myocardial Infarction : T-VENTURE Study
• OE-410 Long-term Effects of Dietary-lifestyle Modification at 6 months after Hospital Discharge in Patients with Acute Myocardial Infarction(OE69,ACS/AMI (Clinical/Treatment) 2 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Ja
• OE-260 Impact of Cardiac Rehabilitation on 10-year Mortality in Patients with Acute Myocardial Infarction(OE44,Exercise Test/Cardiac Rehabilitation (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• OE-256 Effects of Cardiac Rehabilitation are Pronounced in Elderly Patients with Acute Myocardial Infarction(OE44,Exercise Test/Cardiac Rehabilitation (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• FRS-020 Adiponectin Transgenic Mice can Strongly Suppress Neointimal Hyperplasia after Vascular Injury without Enhanced Expression of It's Receptor in Vessels(FRS4,Topics in Peripheral Arterial Disease (H),Featured Research Session (English),The 73rd Annu
• Small LDL-Cholesterol is Superior to LDL-Cholesterol for Determining Severe Coronary Atherosclerosis
• High-Dose Granulocyte-Colony Stimulating Factor Promotes Neointimal Hyperplasia in the Early Phase and Inhibits Neointimal Hyperplasia in the Late Phase After Vascular Injury
• PJ-901 Strong Correlation between Small LDL-Cholesterol and Negative Net Charge Fraction of LDL in Patients with and without Coronary Artery Disease(Lipid disorders(05)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circula
• PJ-233 Elevated Small Dense Low-density Lipoprotein Cholesterol to Risk Marker for Stable Coronary Heart Disease, Independent of Adiponectin and C-reactive protein(Atherosclerosis,clinical(10)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeti
• PJ-167 Remarkably High Levels of Small LDL-cholesterol in Younger Patients with Acute Coronary Syndrome and Metabolic Syndrome(Preventive medicine/Epidemiology/Education(05)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Ci
• PE-502 Not LDL-Cholesterol But Apolipoprotein A1 is an Important Risk Marker for Severe Coronary Atherosclerosis in Patients Treated with Lipid-lowering Drugs(Atherosclerosis, clinical(08)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of
• PE-150 Acceleration of vascular repair after injury in adiponectin-overexpressing mice.(Atherosclerosis, basic(04)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• 2 High Levels of Small Dense LDL-cholesterol as Atherogenic and Metabolic LDL in Patients with Acute Coronary Syndrome(Symposium 3 (SY-03) (IHD) Metabolic Syndrome and Atherosclerosis,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circ
• PJ-811 Effect of Candesartan on the Lipid Metabolism of Hypertensive Patients with Focused on Small Dense LDL-C(Hypertension, clinical-10, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Proposal of a Risk-Stratification System for the Japanese Population Based on Blood Pressure Levels : The Ohasama Study
• PJ-321 The Relationships between Urinary Albumin and Prevalence of Cardiac Diseases in Japanese Patients(PJ054,Kidney/Renal Circulation/CKD 3 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Body Size and Atrial Fibrillation in Japanese Outpatients
• PJ-691 Role of Low EF in Prognosis of Japanese Patients with Ventricular Tachycardia : Comparison with Preserved EF(PJ116,Ventricular Arrhythmia (Clinical/Pathophysiology) (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
• PJ-147 The Role of Atrial Fibrillation in Prognosis in Japanese Patients with Acute Coronary Syndrome(PJ025,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 2 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation So
• PJ-077 Association between Left Atrial Dimension and Prognosis in Japanese Patients with Cardiovascular Diseases(PJ013,Cardiac Function (Clinical) 1 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Impact of reduced renal function on prognosis in Japanese patients with coronary artery disease : a prospective cohort of Shinken Database 2007
• PJ-564 Distribution of Collagen, Macrophages and Fibroblasts in Human Atria with Atrial Fibrillation(PJ095,Arrhythmia, Others (Basic) 2 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Cardioprotective Effect of Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide on Doxorubicin-Induced Cardiomyopathy in Mice
• OE-410 Long-term Effects of Dietary-lifestyle Modification at 6 months after Hospital Discharge in Patients with Acute Myocardial Infarction(OE69,ACS/AMI (Clinical/Treatment) 2 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Ja
• FRS-020 Adiponectin Transgenic Mice can Strongly Suppress Neointimal Hyperplasia after Vascular Injury without Enhanced Expression of It's Receptor in Vessels(FRS4,Topics in Peripheral Arterial Disease (H),Featured Research Session (English),The 73rd Annu
• PJ-901 Strong Correlation between Small LDL-Cholesterol and Negative Net Charge Fraction of LDL in Patients with and without Coronary Artery Disease(Lipid disorders(05)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circula
• PJ-233 Elevated Small Dense Low-density Lipoprotein Cholesterol to Risk Marker for Stable Coronary Heart Disease, Independent of Adiponectin and C-reactive protein(Atherosclerosis,clinical(10)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeti
• PJ-143 Synergistic Effects of Cardiac Rehabilitation with Lipid-lowering Therapy on Amelioration of Small Dense LDL in Patients with Acute Coronary Syndrome(Acute coronary syndrome, basic/clinical-7, The 71st Annual Scientific Meeting of the Japanese Circ
• PJ-657 Mobilization of Mesenchymal Stem/Progenitor Cells into Peripheral Circulation after Acute Myocardial Infarction(PJ110,ACS/AMI (Clinical/Pathophysiology) 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulatio
• PE-116 Erythroblasts in Bone Marrow Cells May Influence Limb Salvage After Cell Transplantation in Patients With Critical Limb Ischemia(Peripheral circulation/Vascular disease(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japane
• PE-455 Increases in Serum Metalloproteinase-1, -13, and Interleukin-6 in the Culprit Coronary Artery in Patients with Acute Myocardial Infarction(Infection/Inflammation/Immunity-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PE-301 Low-density Lipoprotein (LDL)-cholesterol Levels Under Estimate Atherogenic LDL-cholesterol at Onset Acute Coronary Syndrome(Atherosclerosis, clinical-07, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PE-291 Significance of Small Dense LDL-Cholesterol, CRP, and Adiponectin as a Biomarkers to Predict Coronary Events in Stable Coronary Heart Disease(Atherosclerosis, clinical-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PE-169 Effect of Frequent Cardiac Rehabilitation on Heart Rate Recovery after Exercise(Exercise test/Cardiac rehabilitation-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-262 Effects of Pioglitazone on the Metabolic Syndrome Complicated with Hypertension plus Diabetes Mellitus(Cardiovascular pharmacology, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Serum Hepcidin-20 is Elevated during the Acute Phase of Myocardial Infarction
• PE-582 Effects of the Frequency of Exercise-Based Cardiac Rehabilitation on Glucose Tolerance or Intolerance in Patients with Acute Coronary Syndrome(Exercise test/Cardiac rehabilitation-2 (IHD) PE101,Poster Session (English),The 70th Anniversary Annual S
• PJ-462 Circulating Progenitors, Angiotensin II and Renal Function in the Elderly(PJ078,Kidney/Renal Circulation/CKD 4 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• 2 Evaluation of the Prospective Observation of Erythropoietin-Administration for the Treatment of Acute Myocardial Infarction (EPO-AMI)(Late Breaking Clinical Trials II,The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• OE-003 Regional Expression of Tissue Factor in Thrombus in Acute Coronary Syndrome : Immunohistochemical Analysis for Aspiration Samples(Acute coronary syndrome, basic/clinical-1 (IHD) OE1,Oral Presentation (English),The 70th Anniversary Annual Scientific
• Comparative Examination Between Right And Left Coronary Thrombus in Acute Coronary Syndrome : Histological and Immunohistochemical Analysis(Acute Coronary Syndrome/Changing Strategy (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Soc
• P-HDI-05 MOLECULAR GAS-FILM LUBRICATION ANALYSES OF A SLIDER OVER A DISK WITH GROOVES : STATIC AND DYNAMIC FLYING CHARACTERISTICS OF A 3-DOF SLIDER(Head/Disk Interface and Tribology,Technical Program of Poster Session)
• Monitoring of Minimal Residual Disease in Children with Acute Promyelocytic Leukemia by RT-PCR Detecting PML/RARα Chimeric Gene : A Retrospective Study of Clinical Feasibility
• G-CSF Induces Apoptosis of a Human Acute Promyelocytic Leukemia Cell Line, UF-1 : Possible Involvement of Stat3 Activation and Altered Bax Expression
• Improved Survival of Children with Advanced Tumors by Myeloablative Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation in Complete Remission
• Peripheral Blood Stem Cell Transplantation for Hepatoblastoma with Microscopical Residue : A Therapeutic Approach for Incompletely Resected Tumor
• PJ-592 Relationship between Ejection Fraction (EF) and Exercise Gas Exchange in Left Ventricular Failure(PJ099,Exercise Test/Cardiac Rehabilitation 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Significantly lower incidence of early definite stent thrombosis of drug-eluting stents after unrestricted use in Japan using ticlopidine compared to western countries using clopidogrel : A retrospective comparison with western mega-studies
• OE-352 Adiponectin Transgenic Mice Prevents Neointimal Hyperplasia after Vascular Injury(Restenosis basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OE-307 Small Dense Low-Density Lipoprotein (LDL)-Cholesterol is a more Powerful Marker than LDL-Cholesterol in Determining Severe Coronary Atherosclerosis(Atherosclerosis, clinical-02, The 71st Annual Scientific Meeting of the Japanese Circulation Society
• OE-105 Suppression of TNF-alpha Improves the Recovery of Blood Perfusion in Hindlimb Ischemia Model(Growth factor/Cytokine-1(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OE-062 Role of Adiponectin in Vascular Injury Model Using Adiponectin Transgenic Mice(Atherosclerosis, basic-1 (H) OE11,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Postprandial Changes in LDL Phenotypes in Patients with Myocardial Infarction(Atherosclerosis, Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Close Linkage Between Hypoadiponectinemia and Small Dense LDL as a Potent Risk Factor for Coronary Heart Diseases(Preventive Medicine/Epidemiology/Education/Health Policy 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• The Effectiveness of Palliative Resection for Advanced Esophageal Carcinoma : Analysis of 24 Consecutive Cases
• PE-164 Significance of Small Dense Low-density Lipoprotein-Cholesterol Concentrations in Relation to the Severity of Coronary Heart Diseases(Atherosclerosis, clinical-7 (H) PE28,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of th
• Significance of Small Dense Low-Density Lipoprotein-Cholesterol Concentrations as Angiographic and Clinical Severity of Coronary Heart Diseases (Atherosclerosis, Clinical 13 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PE-530 Cardioprotective Effect of Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) on Doxorubicin-Induced Cardiaomyopathy in Mice(PE089,Cardiomyopathy/Hypertrophy (Basic) (M),Poster Session (English),The 73rd Annual Scientific Meeting
• Tumor-Necrosis-Factor-α-Gene-Deficient Mice Have Improved Cardiac Function Through Reduction of Intercellular Adhesion Molecule-1 in Myocardial Infarction
• PJ-418 Usefulness of Time-frequency Analysis during QRS Complex to Detect an Arrhythmogenic Substrate in Brugada Syndrome(PJ071,ECG/Body Surface Potential Mapping/Holter 1 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
• PE-052 The Analysis of 2-year Clinical Outcomes due to the Degree of Endothelial-dependent Vasomotion Induced by Acetylcholine after DES Implantation(PE009,Coronary Revascularization, PCI (DES) 2 (IHD),Poster Session (English),The 73rd Annual Scientific M
• DPJ-057 The Effects of Landiolol in Patients with AMI Complicated with Heart Failure(DPJ10,ACS/AMI (Clinical/Treatment) (IHD),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• OE-072 Increasing Ventricular Pacing Rate Augments Disproportion of Left Ventricular Regional Strain and Perfusion in Patients with Right Ventricular Pacing(OE13,Echo/Doppler (New Technology) (I),Oral Presentation (English),The 73rd Annual Scientific Meet
• FRS-107 Demonstration of Time Sequence of Left Ventricular Mechanical Activation Using Novel Three Dimensional Speckle Tracking Analysis(FRS22,New Echocardiographic Technologies (I),Featured Research Session (English),The 73rd Annual Scientific Meeting of
• PJ-601 Implications of the Epicardial Unipolar ST Changes during Atrial Ablation : Comparison of the Endocardial ST Changes(Arrhythmia, therapy(16)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• 3 Synergistic Effects of Cardiac Rehabilitation with Lipid-lowering Therapy on Amelioration of Atherogenic Dyslipidemia in Patients with Coronary Heart Diseases(Cardiac Rehabilitation Therapy at the Chronic Stage, The 71st Annual Scientific Meeting of the
• Effect of HCl/SO2/H2O on the Deposition of Heavy Metal Vapors in the Cooling Section of an Incineration Plant
• PE-078 Increasing Pacing Rate Augments Local Wall Motion Abnormality in Patients with Right Ventricular Apical Pacing(Echo/Doppler(05)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-127 The efficacy and safety of combination use of h-ANP and landiolol (β blocker) with acute coronary syndrome accompanying heart failure.(Heart failure, clinical(02)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circ
• OE-109 Biventricular Pacing Prevents Progression of Dyssynchrony and Deterioration of Local Wall Motion Present during Univentricular Pacing at Increasing Heart Rates.(Echo/Doppler(01)(I),Oral Presentation(English),The 72nd Annual Scientific Meeting of th
• P590 THE CHANGE OF PLASMA BRAIN NATRIURETIC PERTIDE (BP), PLASMA CATECHOLAMINE (CA) AND AUTONOMIC NEVOUS ACTIVITY (ANA) IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION (AMI)
• Differences in the Association of LDL phenotypes with Postprandial Hypertriglyceridemia in Men With and Without Coronary Heart Diseases (Atherosclerosis, Clinical 13 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• The Mechanism of In-Stent Restenosis in Radius Stent : An Experimental Porcine Study
• Disseminated Fusarium Infection Identified by the Immunohistochemical Staining in a Patient with a Refractory Leukemia
• PJ-132 Development of New Catheter for Transendocardial Cell Transplantation into Heart(Regeneration (angionenesis/myocardial regeneration)-9 (M) PJ22,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soc
• PJ-128 Improvement of Cardiac Function by Bone Marrow Stromal Cell Infusion from Cardiac Vein in Swine Myocardial Infarction Model(Regeneration (angionenesis/myocardial regeneration)-9 (M) PJ22,Poster Session (Japanese),The 70th Anniversary Annual Scienti
• PE-460 IL-6 May Develop Neointimal Hyperplasia through Its Inflammatory Effects(Growth factor/Cytokine-2 (H) PE77,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• OE-303 Provoked Coronary Spasm Affects the Advance of Coronary Lesion in AMI Patients(Acute myocardial infarction, clinical(diagnosis/treatment)(02)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PE-394 Influence for endothelial function after sirolimus-eluting stent implantation(Coronary revascularization, PCI(13)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Effects of Organo-mineral Complexes on Flocculation, Settlement and Vertical Distribution of Bioelements in Soil Suspensions (Environment)
• Prophylaxis of Mucosal Toxicity by Oral Propantheline and Cryotherapy in Children with Malignancies Undergoing Myeloablative Chemo-Radiotherapy
• Refractory autoimmune hemolytic anemia in a patient with chromosome 22q11.2 deletion syndrome
• Heart failure with preserved versus reduced left ventricular systolic function : A prospective cohort of Shinken Database 2004-2005
• Clinical outcome after acute coronary syndrome in Japanese patients : An observational cohort study
• Predominance of Small Dense Low-Density Lipoproteins and Abnormal Glucose Regulation in Patients With Acute Coronary Syndrome
• Isolation of Highly Purified Rat Cerebral Lysosomes Using Percoll Gradients with a Variety of Calcium Concentrations
• Expression of α-catenin and E-cadherin in Oral Squamous Cell Carcinoma and Association with Metastasis to the Regional Lymph Nodes and Survival Rate
• Expression of E-cadherin Adhesion Molecule n Oral Squamous Cell Carcinoma:Association with Metastasis to the Regional Lymph Node and the Influence of the Cancer Chemotherapy on the E-cadherin Expression
• Pt/Ti composite underlayers and Pt interlayers for Co-Cr-Ta Perpendicular magnetic recording media (マルチメディアストレージ 第6回アジア情報記録技術シンポジウム〔英文〕)
• Pt/Ti composite underlayers and Pt interlayers for Co-Cr-Ta Perpendicular Magnetic Recording Media
• Co-Cr-Ta/Pt Bilayered Films for Perpendicular Magnetic Recording Media(Special Issue on Selected Papers from the 4th Asian Symposium for Information Storage Technology)
• Cortical gray matter lesions in acute encephalopathy with febrile convulsive status epilepticus
• Association Between the Small Dense LDL and Postprandial Hyperlipemia in Normotriglyceridemic and Mild Hypertriglyceridemic Patients with Myocardial Infarction (Atherosclerosis, Clinical 13 (IHD), The 69th Annual Scientific Meeting of the Japanese Circula
• G-CSF administered after reperfusion may improve cardiac function in swine AMI model(Apoptosis/Necrosis/Regeneration 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• G-CSF Modulates Vascular Repair Through Acceleration of Re-endothelialization(Restenosis after Angioplasty, Basic/Clinical 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Single-Dose Intravenous Administration of Recombinant Human Erythropoietin Is a Promising Treatment for Patients With Acute Myocardial Infarction : Randomized Controlled Pilot Trial of EPO/AMI-1 Study

もっと見る 閉じる

スポンサーリンク