Comparison of the Compositions of Phospholipid-Associated Fatty Acids in Wild-Type and Extracellular Matrix Tenascin-X-Deficient Mice(Biochemistry/Molecular Biology)
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概要
- 論文の詳細を見る
Tenascin-X (TNX) is a member of the tenascin family of glycoproteins of the extracellular matrix. We previously showed that TNX regulates the synthesis of triglyceride and the composition of triglyceride-associated fatty acids. The aim of the present study was to determine whether TNX controls the synthesis of phospholipids and the composition of phospholipid-associated fatty acids by using TNX-deficient (TNX-/-) mice and TNX-overex-pressing fibroblast cell lines. Thin-layer chromatography of total lipids of the skin and sciatic nerves from wild-type and TNX-/- mice revealed that the amounts of major phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE), in wild-type and TNX-/- mice are not different. Gas chromatography-mass spectrometry showed that the major fatty acid compositions of PC and PE in wild-type and TNX-/- mice are almost the same. Fibroblast cells stably overexpressing TNX also showed almost the same amounts of PC and PE and almost the same fatty acid compositions of PC and PE as those in mock-transfected cells. These results suggest that TNX regulates the amount of triglyceride and the composition of triglyceride-associated fatty acids but not the amount and species of phospholipids or the composition of phospholipid-associated fatty acids.
- 公益社団法人日本薬学会の論文
- 2004-09-01
著者
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Matsumoto Ken-ichi
Dep. Of Biosignaling And Radioisotope Experiment Center For Integrated Res. In Sci. Shimane Univ.
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Matsumoto Ken-ichiro
Departments Of Physical Chemistry Showa Pharmaceutical University
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INOKUCHI Jin-ichi
Department of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Sciences, H
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OKA Seiko
Center for Instrumental Analysis Hokkaido University
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Inokuchi Jin-ichi
Department Of Biomembrane And Biofunctional Chemistry And Crest Japan Science And Technology Agency
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Oka S
Center For Instrumental Analysis Hokkaido University
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Ariga Hiroyoshi
Denartment Of Molecular Biology Graduate School Of Pharmaceutical Sciences Hokkaido University
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MATSUMOTO Ken-ichi
Denartment of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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SATO Takashige
Department of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Sciences, H
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Sato Takashige
Department Of Biomembrane And Biofunctional Chemistry Graduate School Of Pharmaceutical Sciences Hok
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Inokuchi J
Division Of Glycopathology Institute Of Molecular Biomembrane And Glycobiology Tohoku Pharmaceutical
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Matsumoto Ken-ichi
Denartment Of Molecular Biology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Ariga H
Graduate School Of Pharmaceutical Sciences Hokkaido University
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