Effect of Tenascin-X Together with Vascular Endothelial Growth Factor A on Cell Proliferation in Cultured Embryonic Hearts
スポンサーリンク
概要
- 論文の詳細を見る
Tenascin-X (TNX) is a large glycoprotein that appears in extracellular matrices. Previously, we demonstrated that TNX binds to vascular endothelial growth factors A and B (VEGF-A and -B) and that VEGF-B in combination with TNX induces DNA synthesis in endothelial cells via increased signals mediated by the VEGFR1 receptor. In this study, we investigated the effect of TNX with VEGF-A on the cell proliferation in embryonic mouse heart explants from either wild-type (TNX+/+) or TNX-deficient (TNX-/-) mice. The addition of VEGF-A to the explants from TNX+/+ mice increased cell proliferation by 1.5 fold compared with that in TNX-/- mice, indicating that TNX with VEGF family member plays an important role in the control of endothelial cell proliferation in vivo.
- 公益社団法人日本薬学会の論文
- 2001-11-01
著者
-
Matsumoto Ken-ichi
Department of Biosignaling and Radioisotope Experiment, Center for Integrated Research in Science, S
-
Matsumoto Ken-ichi
Dep. Of Biosignaling And Radioisotope Experiment Center For Integrated Res. In Sci. Shimane Univ.
-
ARIGA Hiroyoshi
Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University
-
Ariga Hiroyoshi
Department Of Molecular Biology Graduate School Of Pharmaceutical Sciences Hokkaido University
-
Ikuta Tomoki
Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University
-
MATSUMOTO Ken-ichi
Denartment of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University
-
Matsumoto Ken-ichi
Dep. Of Molecular Biology Graduate School Of Pharmaceutical Sciences Hokkaido Univ.
-
Matsumoto Ken-ichi
Department Of Bioresource Science Faculty Of Agriculture Shimane University
-
Ariga H
Graduate School Of Pharmaceutical Sciences Hokkaido University
-
Ariga Hiroyoshi
Deparnment Of Molecular Biology Graduate School Of Pharmaceutical Sciences Hokkaido University
関連論文
- DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc
- Oxidative Neurodegeneration Is Prevented by UCP0045037, an Allosteric Modulator for the Reduced Form of DJ-1, a Wild-Type of Familial Parkinson's Disease-Linked PARK7
- DJ-1 binds to mitochondrial complex I and maintains its activity
- Increased expression of tenascin-X in thoracic and abdominal aortic aneurysm tissues
- Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN
- Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson's Disease-Linked PARK7
- Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7
- Human Mucus Protease Inhibitor in Airway Fluids Is a Potential Defensive Compound against Infection with Influenza A and Sendai Viruses^1
- Surface Plasmon Resonance Based Sensitive Immunosensor for Benzaldehyde Detection
- Trypsinogen hL Expressed in the Human Lung Is a New Member of the Trypsinogen Family
- Noncompetitive Immunodetection of Benzaldehyde by Open Sandwich ELISA
- Detection of Aromatic Nitro Compounds Using Preconcentrator and SPR Immunosensor
- DJ-1, a Target Protein for an Endocrine Disrupter, Participates in the Fertilization in Mice
- Distribution of DJ-1, Parkinson's Disease-Related Protein PARK7, and Its Alteration in 6-Hydroxydopamine-Treated Hemiparkinsonian Rat Brain
- Durable Antihyperglycemic Effect of 6-O-Caffeoylsophorose with α-Glucosidase Inhibitory Activity in Rats
- α-Glucosidase Inhibitory Profile of Nigerian Medicinal Plants in Immobilized Assay System
- Caffeoylsophorose, a New Natural α-Glucosidase Inhibitor, from Red Vinegar by Fermented Purple-Fleshed Sweet Potato
- Strong Antihyperglycemic Effects of Water-Soluble Fraction of Brazilian Propolis and Its Bioactive Constituent, 3,4,5-Tri-O-caffeoylquinic Acid(Medicinal Chemistry)
- A Novel Method for the Assay of α-Glucosidase Inhibitory Activity Using a Multi-channel Oxygen Sensor
- Synthesis of α,α-Dibromo Esters as Precursors of Ynolates
- α_1-Acid Glycoprotein Suppresses Rat Acute Inflammatory Paw Edema through the Inhibition of Neutrophils Activation and Prostaglandin E_2 Generation(Pharmacology)
- Effects of Benzyl Glucoside and Chlorogenic Acid from Prunus mume on Adrenocorticotropic Hormone (ACTH) and Catecholamine Levels in Plasma of Experimental Menopausal Model Rats(Pharmacognosy)
- Effects of Benzyl Glucoside and Chlorogenic Acid from Prunus mume on Angiotensin Converting Enzyme, Aldosterone and Corticosterone Levels in Rat Plasma
- Effects of α_1-Acid Glycoprotein on Erythrocyte Deformability and Membrane Stabilization(Biopharmacy)
- Adhesive Defect in Extracellular Matrix Tenascin-X-Null Fibroblasts : A Possible Mechanism of Tumor Invasion
- Inhibitory Effects of Benzyl Glucoside and Chlorogenic Acid from Prunus mume on Bradykinin and Prostaglandin E_2 Production in the Abdominal Cavities of Mice
- Characterization of Ligand Binding Sites on the α_1-Acid Glycoprotein in Humans, Bovines and Dogs
- Serum Tenascin-X Strongly Binds to Vascular Endothelial Growth Factor
- Effect of Tenascin-X Together with Vascular Endothelial Growth Factor A on Cell Proliferation in Cultured Embryonic Hearts
- Comparison of the Compositions of Phospholipid-Associated Fatty Acids in Wild-Type and Extracellular Matrix Tenascin-X-Deficient Mice(Biochemistry/Molecular Biology)
- Distinct Glycosylation in Interstitial and Serum Tenascin-X(Molecular and Cell Biology)
- Tenascin-X Induces Cell Detachment through p38 Mitogen-Activated Protein Kinase Activation
- Behavioral Alterations in Mice Lacking the Gene for Tenascin-X
- Extracellular Signal Regulated Protein Kinase and c-Jun N-Terminal Kinase are Involved in m1 Muscarinic Receptor-Enhanced Interleukin-2 Production Pathway in Jurkat Cells
- Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats
- Six-membered Cyclic Phosphonate GABA Antagonists, 2,5-Disubstituted 1,3,2-Dioxaphosphorinanes
- Co-localization with DJ-1 Is Essential for the Androgen Receptor to Exert Its Transcription Activity that Has Been Impaired by Androgen Antagonists (Toxicology)
- Receptor-Mediated Uptake of Human α1-Acid Glycoprotein into Liver Parenchymal Cells in Mice
- Experimental Evaluation of Team Performance in Program Development Based on a Model : Extension of a Programmer Performance Model
- Invasion of Melanoma in Double Knockout Mice Lacking Tenascin-X and Tenascin-C
- Transcription Regulatory Complex Including YB-1 Controls Expression of Mouse Matrix Metalloproteinase-2 Gene in NIH3T3 Cells(Molecular and Cell Biology)
- Increased Expression of Tenascin-X in Thoracic and Abdominal Aortic Aneurysm Tissues
- P-18 Comparison of Body Fat Percentage Measured by Different Methods(Proceedings of the 55th Meeting of Japan Society of Physiological Anthropology)
- Protection Against Dopaminergic Neurodegeneration in Parkinson’s Disease–Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson’s Disease–Linked PARK7
- Effects of Benzyl Glucoside and Chlorogenic Acid from Prunus mume on Angiotensin Converting Enzyme, Aldosterone and Corticosterone Levels in Rat Plasma
- Inhibitory Effects of Benzyl Glucoside and Chlorogenic Acid from Prunus mume on Bradykinin and Prostaglandin E_2 Production in the Abdominal Cavities of Mice
- DJ-1-Mediated Protective Effect of Protocatechuic Aldehyde Against Oxidative Stress in SH-SY5Y Cells
- Rabring7 Degrades c-Myc through Complex Formation with MM-1
- Protection Against Dopaminergic Neurodegeneration in Parkinson's Disease-Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson's Disease-Linked PARK7
- Distribution of DJ-1, Parkinson's Disease-Related Protein PARK7, and Its Alteration in 6-Hydroxydopamine-Treated Hemiparkinsonian Rat Brain