DJ-1 binds to mitochondrial complex I and maintains its activity
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概要
- 論文の詳細を見る
Parkinson's disease (PD) is caused by neuronal cell death, and oxidative stress and mitochondrial dysfunction are thought to be responsible for onset of PD. DJ-1, a causative gene product of a familial form of Parkinson's disease, PARK7, plays roles in transcriptional regulation and anti-oxidative stress. The possible mitochondrial function of DJ-1 has been proposed, but its exact function remains unclear. In this study, we found that DJ-1 directly bound to NDUFA4 and ND1, nuclear and mitochondrial DNA-encoding subunits of mitochondrial complex I, respectively, and was co-localized with complex I and that complex I activity was reduced in DJ-1-knockdown NIH3T3 and HEK293 cells. These findings suggest that DJ-1 is an integral mitochondrial protein and that DJ-1 plays a role in maintenance of mitochondrial complex I activity.
- 2009-12-18
著者
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Takata Kazuyuki
Faculty Of Pharmaceutical Sciences Hoshi University
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Takahashi Kazunori
京都薬科大学 病態生理学
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Takeuchi Kosei
Kan Research Institute Inc. Kobe Mi R&d Center
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Takenawa Tadaomi
Division Of Biochemistry Institute Of Medical Science University Of Tokyo
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Taira Takahiro
Graduate School Of Pharmaceutical Sciences Hokkaido University:crest Japan Science And Technology Co
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Taira T
Graduate School Of Pharmaceutical Sciences Hokkaido University:crest Japan Science And Technology Co
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Maita Hiroshi
Graduate School Of Pharmaceutical Sciences Hokkaido University
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Ariga H
Graduate School Of Pharmaceutical Sciences Hokkaido University
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