Aberrant CD20 Expression in Angioimmunoblastic T-cell Lymphoma
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概要
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We report on a 60-year-old man, having angioimmunoblastic T-cell lymphoma (AITL) with aberrant expression of CD20. The initial biopsy specimen showed features of AITL with the typical CD3+CD20- immunophenotype. As the disease progressed, biopsy specimens of the recurrent lesions showed unusual results for AITL with the CD20+ immunophenotype in both flow cytometry and immunohistochemistry analysis. Double immunostaining confirmed that the lymphoma cells were simultaneously positive for CD3 and CD20. The disease became resistant to combined chemotherapies and the patient died 3 years after the initial diagnosis. Autopsy revealed a composite of AITL and EBV-positive diffuse large B-cell lymphoma. Although it is unknown whether the instability of the CD20 antigen expression is correlated with the behaviour of AITL, the administration of rituximab should be considered as an alternative therapeutic option in such cases.
著者
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Furuya Mitsuko
Department Of Molecular Pathology Graduate School Of Medicine Chiba University
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Takeuchi Kengo
Department Of Laboratory Medicine Research Hospital The Institute Of Medical Science The University
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Yamanaka Shoji
Department Of Applied Chemistry Faculty Of Engineering Hiroshima University
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Ishigatsubo Yoshiaki
Department Of Internal Medicine And Clinical Immunology Yokohama City University Graduate School Of
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Tomita Naoto
Department Of Hematology Graduate School Of Medicine Yokohama City University
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Tachibana Takayoshi
Department Of Hematology Kanagawa Cancer Center
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Fujita Hiroyuki
Department Of Environmental Immuno-dermatology Yokohama City University Graduate School Of Medicine
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Nakamura Naoya
Department Of Hematology Niigata University Graduate School Of Medical And Dental Sciences
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Tachibana Takayoshi
Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Japan
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Furuya Mitsuko
Department of Pathology, Yokohama City University Graduate School of Medicine, Japan
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Nakamura Naoya
Department of Pathology, Tokai University School of Medicine, Japan
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