Mixed-type Multicentric Castleman's Disease Developing during a 17-year Follow-up of Sarcoidosis
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概要
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Multicentric Castleman's Disease (MCD) is a systemic disease characterized by generalized lymphadenopathy and the proliferation of plasma cells. The development of MCD in a patient with preexisting sarcoidosis has not been previously reported. We herein describe a case of MCD developing in a 78-year-old woman with a 17-year history of sarcoidosis. The patient's serum interleukin-6 (IL-6) levels were only slightly elevated; however, the IL-6 levels in the fluid of both pleural effusion and ascites were markedly elevated. The administration of steroid-pulse therapy and prednisolone was ineffective in treating the MCD, although treatment with tocilizumab proved highly effective.
- 社団法人 日本内科学会の論文
著者
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Takeuchi Kengo
Department Of Laboratory Medicine Research Hospital The Institute Of Medical Science The University
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Ikushima Soichiro
Department Of Respiratory Medicine Japanese Red Cross Medical Center
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Kondoh Keisuke
Department Of Biological Sciences Tokyo Institute Of Technology
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Kumasaka Toshio
Department Of Human Pathology Juntendo University School Of Medicine
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Takemura Tamiko
Department Of Pathology Japan Red Cross Medical Center
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Kamiya Hiroyuki
Department Of Microbiology Tokyo Medical University
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Ando Tsunehiro
Department Of Infectious Diseases Japanese Red Cross Medical Center
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Kumasaka Toshio
Department of Pathology, Japanese Red Cross Medical Center, Japan
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Awano Nobuyasu
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
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Inomata Minoru
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
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Satake Kohta
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
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Moriya Atsuko
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
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Moriya Atsuko
Department of Infectious Disease, Japanese Red Cross Medical Center, Japan
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Awano Nobuyasu
Department of Internal Medicine, Social Insurance Chuo General Hospital, Japan
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Inomata Minoru
Department of Respiratory Medicine, Japanese Red Cross Medical Center
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Kamiya Hiroyuki
Department of Cardiovascular Surgery and Research Group for Experimental Surgery, Heinrich Heine University, Medical Faculty
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Takemura Tamiko
Department of Pathology, Japanese Red Cross Medical Center, Japan
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Kamiya Hiroyuki
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
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Ando Tsunehiro
Department of Infectious Disease, Japanese Red Cross Medical Center, Japan
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