Lymphangioleiomyomatosis Diagnosed by Immunocytochemical and Genetic Analysis of Lymphangioleiomyomatosis Cell Clusters Found in Chylous Pleural Effusion
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概要
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A 37-year-old woman presented with a cough and discomfort in the chest. Computed tomography revealed the right pleural effusion and a number of cysts in the lungs. Thoracentesis revealed LAM cell clusters (LCC) in chylous pleural effusion, confirmed by immunocytochemical examinations showing that the cells at the center of cluster were LAM cells positive for α-smooth muscle actin and HMB45 and the outer layer was lymphatic endothelium cells. When LCC were cultured in vitro, the loss of heterozygosity of TSC2 markers was detected. This case illustrates that LAM can be diagnosed by the identification of LCC without an invasive biopsy if complicated with chylous effusion.
著者
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Seyama Kuniaki
Department Of Respiratory Medicine
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IWASE Akihiko
Department of Infectious and Respiratory Medicine, Showa General Hospital
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Hirama Michihiro
Department Of Respiratory Medicine National Hospital Organization Tokyo Hospital
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Kumasaka Toshio
Department Of Human Pathology Juntendo University School Of Medicine
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Mitani Keiko
Department Of Human Pathology Juntendo University School Of Medicine
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Sasaki Shin-ichi
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Takahashi Kazuhisa
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Atsuta Ryo
Department of Respiratory Medicine, Juntendo University School of Medicine
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Iwase Akihiko
Department of Respiratory Medicine, Tokyo Metropolitan Koto Geriatric Medical Center
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Gunji Yoko
Department of Respiratory Medicine, Juntendo University School of Medicine
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Sasaki Shin-ichi
Department of Respiratory Medicine, Juntendo University Urayasu Hospital
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