Malignant Epithelioid Angiomyolipoma in the Kidney and Liver of a Patient with Pulmonary Lymphangioleiomyomatosis: Lack of Response to Sirolimus
スポンサーリンク
概要
- 論文の詳細を見る
A 26-year-old woman with lymphoangioleiomyomatosis (LAM) was hospitalized for the surgical excision of a giant abdominal tumor of right kidney origin. The pathological diagnosis of the tumor was conventional angiomyolipoma (AML). After 8 months, 2 liver tumors appeared and grew rapidly. The tumors were resected, and the pathological finding of these tumors was epithelioid AML. Thereafter, metastatic multiple lung tumors appeared, and there was local recurrence of the liver tumors. Sirolimus, an mTOR protein inhibitor, was used to treat epithelioid AML. However, the drug did not inhibit the rapid growth of the tumor at all. This finding suggests that sirolimus might not be effective against epithelioid AML, and in such cases, complete surgical resection should be the treatment of choice.
- 社団法人 日本内科学会の論文
著者
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Seyama Kuniaki
Department Of Respiratory Medicine
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HARANAGA Syusaku
Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Graduate Sch
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Shiraishi Masayuki
Department Of Surgery Graduate School Of Medical Science University Of Ryukyus
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Kumasaka Toshio
Department Of Human Pathology Juntendo University School Of Medicine
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Oshiro Yoshinori
Department Of Urology Faculty Of Medicine University Of The Ryukyus
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Tateyama Masao
Department Of Infectious Respiratory And Digestive Medicine Control And Prevention Of Infectious Dis
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Fujita Jiro
Department Of Infectious Respiratory And Digestive Medicine Control And Prevention Of Infectious Dis
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Uchihara Teruhito
Department Of Medicine And Therapeutics Control And Prevention Of Infectious Diseases (first Departm
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Higa Futoshi
Department Of Infectious Respiratory And Digestive Medicine Control And Prevention Of Infectious Dis
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Yara Satomi
Department Of Infectious Respiratory And Digestive Medicine Control And Prevention Of Infectious Dis
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Kumasaka Toshio
Department of Pathology, School of Medicine, Juntendo University
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Tateyama Masao
Department of Infections, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan
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Tateyama Masao
Department of Medicine and Therapeutics, Prevention, Control of Infectious Diseases, School of Medicine, University of the Ryukyus
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Higa Futoshi
Department of Infections, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan
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Yara Satomi
Department of Medicine and Therapeutics, Prevention, Control of Infectious Diseases, School of Medicine, University of the Ryukyus
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Oshiro Yoshinori
Department of Urology, School of Medicine, University of the Ryukyus
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