Depression of Local Cell-mediated Immunity and Histological Characteristics of Disseminated AIDS-related Mycobacterium avium Infection after the Initiation of Antiretroviral Therapy
スポンサーリンク
概要
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Objective The aim of the present study was to examine the immunohistological characteristics of disseminated Mycobacterium avium infection after the initiation of antiretroviral therapy (ART) for acquired immunodeficiency syndrome (AIDS). Methods We histologically investigated five autopsied AIDS patients with systemic M. avium infection. Results The inflammatory cell composition in the affected tissues was assessed using immunohistochemistry. The celiac lymph nodes and intestinal canal were the most commonly involved organs in the AIDS cases. The most common histological feature was unstructured aggregation of histiocytes. Immunohistochemistry revealed depression of CD4+, CD8+ and CD57+ cells in the gut lamina propria and mesenteric lymph nodes. Conclusion These findings suggest that local cell-mediated immunity is depressed in affected tissues and that the primary histological feature is poor organization of granulomas in mycobacterial lesions, despite the administration of adequate ART.
著者
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Teruya Katsuji
AIDS Clinical Center, National Center for Global Health and Medicine, Japan
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Oka Shinichi
Aids Clinical Center International Medical Center Of Japan
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Furugen Makoto
Department Of Medicine And Therapeutics Control And Prevention Of Infectious Diseases (first Departm
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Kikuchi Yoshimi
Aids Clinical Center International Medical Center Of Japan
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Hibiya Kenji
Department Of Infectious Respiratory And Digestive Medicine Control And Prevention Of Infectious Dis
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Tateyama Masao
Department Of Infectious Respiratory And Digestive Medicine Control And Prevention Of Infectious Dis
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Fujita Jiro
Department Of Infectious Respiratory And Digestive Medicine Control And Prevention Of Infectious Dis
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Tasato Daisuke
Department Of Infectious Respiratory And Digestive Medicine Control And Prevention Of Infectious Dis
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Nakamura Hideta
Department Of Infectious Respiratory And Digestive Medicine Control And Prevention Of Infectious Dis
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Higa Futoshi
Department Of Infectious Respiratory And Digestive Medicine Control And Prevention Of Infectious Dis
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Endo Hisako
Division of Cardiology, Nephrology, Pulmonology and Neurology, Department of Internal Medicine, Asahikawa Medical University, Japan
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Mochizuki Makoto
Division of Pathology, Kyorin University School of Medicine, Japan
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Tateyama Masao
Department of Infections, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan
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Oka Shinichi
AIDS Clinical Center, National Center for Global Health and Medicine Hospital, Japan
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Tateyama Masao
Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan
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Tasato Daisuke
Department of Infections, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan
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Endo Hisako
Division of Pathology and Laboratory Medicine, Edogawa Hospital, Japan
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Nakamura Hideta
Department of Infections, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan
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Furugen Makoto
Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan
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Higa Futoshi
Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan
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Higa Futoshi
Department of Infections, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan
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Kikuchi Yoshimi
AIDS Clinical Center, National Center for Global Health and Medicine Hospital, Japan
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