Detection of Toxoplasma gondii, Epstein-Barr Virus, and JC Virus DNAs in the Cerebrospinal Fluid in Acquired Immunodeficiency Syndrome Patients with Focal Central Nervous System Complicatinos
スポンサーリンク
概要
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Object Toxoplasmic encephalitis (TE), primary central nervous system lymphoma (PCNSL) and progressive multifocal leukoencephalopathy (PML) are major central nervous system (CNS) diseases in patients with acquired immunodeficiency syndrome (AIDS). We assessed the diagnostic value of polymerase chain reaction (PCR) in the detection of DNAs of Toxoplasma gondii (T. gondii), Epstein-Barr virus (EBV) and JC virus (JCV) in the cerebrospinal fluid (CSF). Methods We compared the PCR results with those of pathological findings at autopsy. Patients or Materials The present study included 23 autopsies representing those in whom CSF samples were obtained before death while the patient was hospitalized or at autopsy. Results The threshold levels for PCR detection were 4 tachyzoites of T. gondii, 5-15 genomes of EBV and 10 genomes of JCV. We identified T. gondii DNA in 4 out of 5 autopsy-defined cases of TE, EBV DNA in 5 out of 5 cases with PCNSL, and JCV DNA in 2 out of 2 cases with PML. The specificity of PCR was 100% in TE, 78 % in PCNSL, and 100 % in PML. Conclusion Although the number of cases was relatively small in this study, PCR correctly identified T. gondii DNA in those cases in which PML or PCNSL was the sole clinical diagnosis. Our results indicate that PCR examination of CSF is a clinically useful tool for the diagnosis of focal brain lesions in patients with AIDS.(Internal Medicine 38: 556-562, 1999)
- 社団法人 日本内科学会の論文
著者
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Gatanaga Hiroyuki
AIDS Clinical Center, National Center for Global Health and Medicine, Japan
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Oka Shinichi
AIDS Clinical Center, National Center for Global Health and Medicine, Japan
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Oka Shinichi
Aids Clinical Center International Medical Center Of Japan
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Yasuoka A
The Aids Clinical Center International Medical Center Of Japan
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Yasuoka Akira
Fourth Department Of Medicine International Medical Center Of Japan Shinjuku-ku
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Tachikawa Natsuo
AIDS Clinical Center, International Medical Center of Japan
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KIMURA Satoshi
AIDS Clinical Center, International Medical Center of Japan
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Kimura Satoshi
Aids Clinical Center International Medical Center Of Japan
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Ito Akira
Second Department Of Internal Medicine Oita Medical University
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Ito Akira
Division Of Clinical Laboratory Medicine Yokohama City University Hospital
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Goto Mieko
The Department Of Infectious Diseases Institute Of Medical Science University Of Tokyo
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KIMURA Satoshi
the Department of Diabetes and Metabolism, Faculty of Medicine, Tokyo University
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IWAMOTO Aikichi
the Department of Infectious Disease, Institute of Medical Science, University of Tokyo
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Iwamoto Aikichi
Department Of Infectious Diseases Institute Of Medical Science University Of Tokyo
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Iwamoto Aikichi
Department Of Infectious Diseases Institute Of Medical Science The University Of Tokyo
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Iwamoto Aikichi
Department Of Infectious Diseases And Applied Immunology The Institute Of Medical Science The Univer
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Iwamoto Aikichi
Division Of Infectious Diseases Advanced Clinical Research Center Institute Of Medical Science The U
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星野 芳彦
Division Of Pulmonary & Critical Care Medicine New York University Medical Center
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Hoshino Yoshihiko
The Department Of Infectious Diseases Institute Of Medical Science University Of Tokyo
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Gatanaga Hiroyuki
Aids Clinical Center International Medical Center Of Japan
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Iwamoto A
Department Of Infectious Disease And Applied Immunology University Of Tokyo
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YASUOKA Akira
AIDS Clinical Center, International Medical Center of Japan
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TACHIKAWA Natsuo
the AIDS Clinical Center, International Medical Center of Japan
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Oka Shinichi
Fourth Department Of Medicine International Medical Center Of Japan Shinjuku-ku
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Katano Harutaka
Department Of Pathology National Institute Of Infectious Diseases
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WAKABAYAHSI Tomo
the Department of Pathology, Tokyo Senbai Hospital
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KATANO Harutaka
the Department of Pathology, National Institute of Infectious Diseases
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Iwamoto Aikichi
Department Of Infectious Disease And Applied Immunology University Of Tokyo
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Wakabayahsi Tomo
The Department Of Pathology Tokyo Senbai Hospital
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Tachikawa Natsuo
The Aids Clinical Center International Medical Center Of Japan
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Kimura Satoshi
The Department Of Diabetes And Metabolism Faculty Of Medicine Tokyo University
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