Drug-Induced Acute Interstitial Nephritis Mimicking Acute Tubular Necrosis after Initiation of Tenofovir-Containing Antiretroviral Therapy in Patient with HIV-1 Infection
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概要
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We describe a case of 68-year-old Japanese man with HIV-1 infection who developed acute kidney injury with prominent tubular dysfunction immediately after starting tenofovir-containing antiretroviral therapy. Antiretroviral therapy was discontinued in two weeks but renal function, as well as tubular function, did not shown full recovery even at a 3-year follow-up examination. Acute tubular necrosis, a rare but well-known side effect of tenofovir, was suspected, but kidney biopsy confirmed interstitial nephritis. It is important to distinguish drug-induced interstitial nephritis from acute tubular necrosis, because early steroid administration can improve renal dysfunction caused by acute interstitial nephritis.
著者
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Teruya Katsuji
AIDS Clinical Center, National Center for Global Health and Medicine, Japan
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Yazaki Hirohisa
AIDS Clinical Center, National Center for Global Health and Medicine, Japan
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Kikuchi Yoshimi
AIDS Clinical Center, National Center for Global Health and Medicine, Japan
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Oka Shinichi
Aids Clinical Center International Medical Center Of Japan
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Kikuchi Yoshimi
Aids Clinical Center International Medical Center Of Japan
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Gatanaga Hiroyuki
Aids Clinical Center International Medical Center Of Japan
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Hinoshita Fumihiko
Department Of Nephrology National Center For Global Health And Medicine
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Nishijima Takeshi
AIDS Clinical Center, National Center for Global Health and Medicine, Japan
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Tasato Daisuke
AIDS Clinical Center, National Center for Global Health and Medicine, Japan
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Hoshimoto Kazufusa
Department of Pathology, National Center for Global Health and Medicine, Japan
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