A Randomized Trial of Reduced Doses of Azidothymidine in Japanese Patients with Human Immunodeficiency Virus Type 1 Infection.
スポンサーリンク
概要
- 論文の詳細を見る
Adverse reactions to the standard dose (1, 200 mg/day-1, 500mg/day) of azidothymidine (AZT) are serious. An in vitro pharmacokinetic study of intracellular AZT-5'-triphosphate suggested the feasibility of a clinical trial with reduced doses of AZT. A randomized trial with reduced doses of AZT (group A ; 400mg/day, n=15, group B ; 800mg/day, n=13), was conducted enrolling 28 patients with human immunodeficiency virus infection. The effective rate of AZT on CD4+ lymphocyte counts was similar for both groups, but the duration of the effect of AZT was significantly longer in group A (p<0.05). In group B, adverse reactions were more frequently observed (p<0.01), and AZT was withdrawn or the dose was reduced more frequently (p<0.05). These results suggest that AZT at a dose of 400 mg/day is less toxic, and is more beneficial for long-term treatment.(Internal Medicine 31 : 871-876, 1992)
- 社団法人 日本内科学会の論文
著者
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Kimura Satoshi
The Department Of Diabetes And Metabolism Faculty Of Medicine Tokyo University
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KIMURA Satoshi
the Department of Infectious Diseases and Applied Immunology, the Institute of Medical Science, University of Tokyo
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OKA Shinichi
the Department of Infectious Diseases and Applied Immunology, the Institute of Medical Science, University of Tokyo
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TOYOSHIMA Takuo
the Department of Infectious Diseases and Applied Immunology, the Institute of Medical Science, University of Tokyo
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HIRABAYASHI Yoshihiro
the Department of Infectious Diseases and Applied Immunology, the Institute of Medical Science, University of Tokyo
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KIKUCHI Yoshimi
the Department of Infectious Diseases and Applied Immunology, the Institute of Medical Science, University of Tokyo
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MITAMURA Keiji
the Department of Infectious Diseases and Applied Immunology, the Institute of Medical Science, University of Tokyo
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SHIMADA Kaoru
the Department of Infectious Diseases and Applied Immunology, the Institute of Medical Science, University of Tokyo
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- A Randomized Trial of Reduced Doses of Azidothymidine in Japanese Patients with Human Immunodeficiency Virus Type 1 Infection.
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