Immunohistochemical Findings of an Autopsied Lung Specimen from a Patient with Pandemic Influenza (A/H1N1pdm) Virus Infection
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概要
- 論文の詳細を見る
A 24-year-old female presented with fever and dry cough. Influenza A virus infection was suspected and the patient was treated with neuraminidase inhibitors. Five days after diagnosis, the patient developed persistent fever and dyspnea, and was diagnosed with severe pneumonia. Despite intensive treatment, the pneumonia worsened and the patient died 14 days after admission. At autopsy, a diffuse alveolar damage (DAD) pattern was observed. Immunohistochemical evaluation indicated severe epithelial damage, resulting in successive regeneration of alveolar type II cells followed by marked proliferation of smooth muscle cells and an increase of collagen fibers at the tip of alveolar orifices.
著者
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Ohtsuki Yuji
Division Of Pathology Matsuyama-shimin Hospital
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Tsutsumi Yutaka
Department Of Internal Medicine Hakodate Municipal Hospital
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Higa Hajime
Department Of Physical Electronics Tokyo Institute Of Technology
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Nakazato Iwao
Department Of Pathology Ryukyu University School Of Medicine
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Fujita Jiro
Department Of Infectious Respiratory And Digestive Medicine Control And Prevention Of Infectious Dis
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Azuma Masato
Department of Internal Medicine, Okinawa Prefectural Nanbu Medical Center, Japan
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Tateyama Masao
Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases (The First Department of Internal Medicine), Faculty of Medicine, University of the Ryukyus, Japan
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Tateyama Masao
Department of Infections, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan
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Cash Haley
Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases (The First Department of Internal Medicine), Faculty of Medicine, University of the Ryukyus, Japan
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Higa Futoshi
Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases (The First Department of Internal Medicine), Faculty of Medicine, University of the Ryukyus, Japan
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Higa Futoshi
Department of Infections, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan
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Kin Meika
Department of Internal Medicine, Okinawa Prefectural Nanbu Medical Center, Japan
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Kakazu Koichiro
Department of Internal Medicine, Okinawa Prefectural Nanbu Medical Center, Japan
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Toume Masahiko
Department of Internal Medicine, Okinawa Prefectural Nanbu Medical Center, Japan
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