"Mucin Types" in Normal and Neoplastic Colonic Goblet Cells: A Mucin Histochemical Study

概要

論文の詳細を見る
Goblet cells in normal colon mucosa from 100 individuals histochemically showed two major "mucin types" in sialic acid composition. One type revealed mixed reactivities for N-acetyl-neuraminic acid (NANA, abbreviated C_0), 7-O- acylated NANA (C_7) and 9-O-acylated NANA (C_9), and represented 25% of the individuals examined. The other type of mucin, seen in 69% of the cases, exhibited reactivity for 8-O-acylated NANA or pluri-O-acylated NANA (C_8). C_0 and C_8 were observed simultaneously in 5% of the individuals. In addition, 8% displayed a mosaic pattern in which isolated "blue" crypts containing sialic acids of the C_0+C_7+C_9 type were detected in the "red" colonic mucosa, which was predominantly C_8. Little correlation was found between the mucin types and their site in the colon, or with the age, sex, ABO blood groups and degree of sulphation. Oacylated NANA was also observed, though reduced in amount, in all 22 colonic adenocarcinomas in which evaluable numbers of neoplastic goblet cells were found. The mucin types in colon cancer were fundamentally indistiguishable from those seen in the surrounding noncancerous colonic mucosa.