Mosaic-like distribution of endothelial cell antigens in capillaries and juxta-alveolar microvessels in the normal human lung
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概要
- 論文の詳細を見る
The distribution patterns of endothelial cell antigens, including thrombomodulin and von Willebrand factor (vWf), were studied in normal lung tissues obtained from distant areas of solitary nodules (seven adenocarcinomas and four hamartomas). By single immunoalkaline phosphatase and dual immunofluorescence stainings, the plasma membranes of alveolar capillary endothelium showed linear distribution of thrombomodulin, but their cytoplasm was rarely reactive for vWf (thrombomodulin-dominant pattern). Microvessels with a diameter larger than 10μm located in the connective tissue zones demonstrated band-like reaction for vWf in their cytoplasm, and their plasma membranes often lacked reactivity for thrombomodulin (vWf-dominant pattern). The juxta-alveolar microvessels located along the borders between the alveolar-and connective-tissue zones showed mosaic-like pattern of distribution for these antigens. The pulmonary venules and peribronchial microvessels measuring up to 40μm in diameter, demonstrated the expression of thrombomodulin along the plasma membrane, and that of vWf in the cytoplasm. Capillaries of the bronchial circulation were also characterized by mosaic-like pattern of distribution. Both antigens were often expressed in a single cytoplasmic segment. The heterogeneous distribution pattern of these antigens suggests topographic difference in endothelial cell function to maintain coagulatory and anticoagulatory balance in the normal human lung.
- 日本医科大学の論文
- 2001-03-25
著者
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Takemura Tamiko
Pathology Laboratory Nippon Red Cross Hospital Center
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Takemura Tamiko
Department Of Pathology Japanese Red Cross Medical Center Tokyo
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Ghazizadeh M
Departments Of Molecular Pathology And Biochemistry And Cell Biology Institute Of Development And Ag
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JIN Enjing
Department of Pathology, Institute of Gerontology, Nippon Medical School
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KAWANAMI Oichi
Department of Pathology, Institute of Gerontology, Nippon Medical School
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Ghazizadeh Mohammad
Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School
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FUJIWARA MASAKAZU
Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School
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Gomibuchi Makoto
Surgery Section, Hokusoh Hospital Nippon Medical School
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Jiang Li
Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School
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Ohaki Yoshiharu
Surgical Pathology Section, Hokusoh Hospital, Nippon Medical School
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Fujiwara Masakazu
Departments Of Molecular Pathology And Biochemistry And Cell Biology Institute Of Development And Ag
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Ghazizadeh Mohammad
Department Of Molecular Pathology Institute Of Gerontology Nippon Medical School
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Ohaki Yoshiharu
Pathology Section Hokusoh Hospital Nippon Medical School
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Ohaki Yoshiharu
Surgical Pathology Nippon Medical School Chiba Hokusoh Hospital
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Jiang Li
Department Of Molecular Pathology Institute Of Gerontology Nippon Medical School
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Jin Enjing
Departments Of Molecular Pathology And Biochemistry And Cell Biology Institute Of Development And Ag
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Jin Enjing
Department Of Pathology Institute Of Gerontology Nippon Medical School
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Kawanami Oichi
Departments Of Molecular Pathology And Biochemistry And Cell Biology Institute Of Development And Ag
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Kawanami Oichi
Department Of Molecular Pathology Institute Of Gerontology Nippon Medical School
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Gomibuchi Makoto
Surgery Section Hokusoh Hospital Nippon Medical School
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Takemura Tamiko
Department Of Pathology Japan Red Cross Medical Center
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Jiang Li
Department Of Electrical And Electronic Engineering Tokyo Institute Of Technology
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Jiang Li
Department of Applied Physics and Materials Research Centre, The Hong Kong Polytechnic University, Hong Kong, P. R. China
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