Supplementation of Heterologous Complement Induces Anti-Thy-1.1 Nephritis in the Mongolian Gerbil (Meriones unguiculatus).
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概要
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Anti-Thy-1.1 nephritis in the rat is a popular experimental model for mesangial proliferative glomerulonephritis (GN). This model is characterized by direct binding of anti-Thy-1.1 antibody with Thy-1.1 antigen expressed on mesangial cells (MCs) of glomeruli in the rat. A single injection of anti-rat thymocyte serum (ARTS) results in GN with proteinuria and extensive mesangiolysis. Development of mesangiolysis and proteinuria are complement-dependent. We previously demonstrated Thy-1.1 antigen, similar to the rat, in thymocytes, brain cells and MCs of the kidney in the Mongolian gerbil (MG). In this study, we attempted to develop a MG nephritis model, but an injection of ARTS did not induce GN. An additional injection of guinea pig serum as a complement after ARTS injection resulted in anti-Thy-1.1 nephritis in MG. Degeneration of MCs and neutrophil infiltration were observed 1 hr after GP serum injection. Mesangiolysis and fibrin exudation occurred 12 hr after the injection and MC proliferation was apparent 7 days after the injection. In the complement-dependent hemolytic test, MG serum could not hemolyze sheep erythrocytes. These results suggested low activity, or depletion of some factors, in complements of MG serum.
- 公益社団法人 日本獣医学会の論文
著者
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SHIMIZU-SUGANUMA Masumi
Department of Laboratory Animal Science, Nippon Medical School
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Shimizu-suganuma Masumi
Department Of Laboratory Animal Science Nippon Medical School
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Ghazizadeh Mohammad
Department Of Molecular Pathology Institute Of Gerontology Nippon Medical School
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Ishizaki Masamichi
Department Of Analytic Human Pathology Nippon Medical School
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SHICHINOHE Kazuhiro
Department of Anatomy, Nippon Medical Scool
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