Heterogeneous Distribution of Thrombomodulin and von Willebrand Factor in Endothelial Cells in the Human Pulmonary Microvessels
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概要
- 論文の詳細を見る
Laser scanning confocal fluorescence microscopy techniques were used to study the localization of von Willebrand factor (vWf; Factor VIII-related antigen) and thrombomodulin (transmembrane receptor for thrombin) in the microvascular endothelial cells in the normal human lung. Tissues were obtained from lobectomy specimens resected for solitary nodules (7 adenocarcinomas and 4 hamartomas) from 11 patients. The plasma membranes of the capillary endothelial cells in the alveolar zones (A-zones) showed red linear fluorescence for thrombomodulin. However, their cytoplasm was mostly unreactive for vWf. The microvessels which were located in the connective tissue (C-zones), including peribronchial, and subpleural areas and large vascular walls, consistently demonstrated band-like green fluorescence for vWf in their cytoplasm, and their plasma membranes usually lacked reactivity for thrombomodulin. Only a limited number of peribronchial capillaries measuring<10μm in diameter showed a mosaic-like appearance, in which red fluorescence along the plasma membranes was found together with green fluorescence in the subjacent cytoplasm. In the juxtaalveolar (J-zones) microvessels located along the borders between A- and C-zones, and measuring up to 40μm in diameter, the endothelial cells showed a mosaic-like pattern of distribution of the two antigens. However, the localization of thrombomodulin in the J-zone microvessels was separate and independent from that of vWf. The thrombomodulin-reactive cells were directly connected to the alveolar capillary endothelial cells. Heterogeneous patterns of distribution of thrombomodulin and vWf suggest that topographic differences of endothelial function occur to maintain a balance of coagulation and anticoagulation in the normal human lung.
- 日本医科大学の論文
- 2001-03-25
著者
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Takemura Tamiko
Pathology Laboratory Nippon Red Cross Hospital Center
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Takemura Tamiko
Department Of Pathology Japanese Red Cross Medical Center Tokyo
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Ferrans Victor
Pathology Section National Heart Lung And Blood Institute National Institutes Of Health
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Ferrans Victor
Pathology And Clinical Research Laboratory Nippon Medical School Second Hospital:shanghai Institute
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Ghazizadeh M
Departments Of Molecular Pathology And Biochemistry And Cell Biology Institute Of Development And Ag
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Shimizu Hajime
Department Of Molecular Pathology Institute Of Gerontology Nippon Medical School
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JIN Enjing
Department of Pathology, Institute of Gerontology, Nippon Medical School
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KAWANAMI Oichi
Department of Pathology, Institute of Gerontology, Nippon Medical School
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Takemura Tamiko
Department Of Pathology Japanese Red Cross Medical Center
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Ghazizadeh Mohammad
Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School
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FUJIWARA MASAKAZU
Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School
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NAGASHIMA MIKIO
Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School
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Arai Satoru
Pathology Section, Hokusoh Hospital Nippon Medical School
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Gomibuchi Makoto
Surgery Section, Hokusoh Hospital Nippon Medical School
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Jiang Li
Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School
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Ohaki Yoshiharu
Surgical Pathology Section, Hokusoh Hospital, Nippon Medical School
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Arai Satoru
Surgical Pathology, Hokusoh Hospital, Nippon Medical School
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Takeda Kazuyo
Pathology Section, National Heart, Lung and Blood Institute, National Institutes of Health
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Yu ZuXi
Pathology Section, National Heart, Lung and Blood Institute, National Institutes of Health
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Fujiwara Masakazu
Departments Of Molecular Pathology And Biochemistry And Cell Biology Institute Of Development And Ag
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Ghazizadeh Mohammad
Department Of Molecular Pathology Institute Of Gerontology Nippon Medical School
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Ohaki Yoshiharu
Pathology Section Hokusoh Hospital Nippon Medical School
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Ohaki Yoshiharu
Surgical Pathology Nippon Medical School Chiba Hokusoh Hospital
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Jiang Li
Department Of Molecular Pathology Institute Of Gerontology Nippon Medical School
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Yu Zuxi
Pathology Section National Heart Lung And Blood Institute National Institutes Of Health
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Jin Enjing
Departments Of Molecular Pathology And Biochemistry And Cell Biology Institute Of Development And Ag
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Jin Enjing
Department Of Pathology Institute Of Gerontology Nippon Medical School
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Arai Satoru
Pathology Section Hokusoh Hospital Nippon Medical School
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Nakajima Michiko
Department Of Molecular Pathology Institute Of Gerontology Nippon Medical School
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Takeda Kazuyo
Pathology Section National Heart Lung And Blood Institute National Institutes Of Health
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Kawanami Oichi
Departments Of Molecular Pathology And Biochemistry And Cell Biology Institute Of Development And Ag
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Kawanami Oichi
Department Of Molecular Pathology Institute Of Gerontology Nippon Medical School
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Gomibuchi Makoto
Surgery Section Hokusoh Hospital Nippon Medical School
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Takemura Tamiko
Department Of Pathology Japan Red Cross Medical Center
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Jiang Li
Department Of Electrical And Electronic Engineering Tokyo Institute Of Technology
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Jiang Li
Department of Applied Physics and Materials Research Centre, The Hong Kong Polytechnic University, Hong Kong, P. R. China
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Shimizu Hajime
Department of Electronics and Computer Science, Tokyo University of Science
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