Comparative Studies of Dialyzability of Levofloxacin and Amlodipine Using in Vitro Dialysis System with Three Different Types of Dialyzers
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概要
- 論文の詳細を見る
In the pharmacotherapy of patients receiving hemodialysis, the possible exclusion of an administered drug by hemodialysis should be recognized. The present study was undertaken to predict dialyzability of a drug during hemodialysis using an in vitro dialysis system with three different dialyzers made from high performance membrane. Levofloxacin having relatively low binding-affinity to plasma protein was removed ideally during in vitro dialysis. Amlodipine was also eliminated from the blood, although it is generally believed that such drugs with high binding affinity to plasma protein are removed less efficiently. Examination of the adsorption rate and clearance of the drug revealed that disappearance of amlodipine was due to its adsorption to dialysis membrane and its circuit. Thus, drugs with high protein binding-affinity may possibly be removed by dialyzers with high performance membrane.
- 公益社団法人日本薬学会の論文
- 1999-10-31
著者
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Yamane Shinji
Sagami Chemical Research Center
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NAKAJIMA Yuki
Department of Surgery II, Nippon Medical School
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MOCHIZUKI Mayumi
Department of Pathology, School of Medicine, Kitasato University
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UEDA Shiro
Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba
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Ueda S
Chiba Univ. Chiba Jpn
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Ueda Shiro
Department Of Drug Information And Communication Graduate School Of Pharmaceutical Sciences
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Oda Shigeto
Division Of Blood Purification Chiba University Hospital
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Nakajima Yuki
Department Of Applied Life Sciences Niigata University Of Pharmacy And Applied Life Sciences
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YAMAGATA SHIN-ICHI
Department of Pharmacy, Chiba University Hospital
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Yuda Rieko
Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba
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Amano Fumi
Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba
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Yamane Shinji
Division of Blood Purification, Chiba University Hospital
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Ishii Masayuki
Division of Blood Purification, Chiba University Hospital
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Mochizuki M
Chiba Univ. Chiba Jpn
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Mochizuki Mayumi
Department Of Drug Information And Communication Graduate School Of Pharmaceutical Sciences Chiba Un
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Amano Fumi
Department Of Drug Information And Communication Graduate School Of Pharmaceutical Sciences Chiba Un
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Yamane Shinji
Division Of Blood Purification Chiba University Hospital
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Yuda Rieko
Department Of Drug Information And Communication Graduate School Of Pharmaceutical Sciences Chiba Un
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Yamagata Shin-ichi
Department Of Drug Information And Communication Graduate School Of Pharmaceutical Sciences Chiba Un
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Nakajima Yuki
Department Of Drug Information And Communication Graduate School Of Pharmaceutical Sciences Chiba Un
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Ishii Masayuki
Division Of Blood Purification Chiba University Hospital
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Mochizuki Mayumi
Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University
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Nakajima Yuki
Department of Applied Chemistry, Faculty of Engineering, Saitama University, 255 Shimo-okubo, Sakura, Saitama 338-8570, Japan
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