Antibacterial Activity of Two Alkylamines Integrated an Indane Scaffold : Mimicry of a Complementary Unit on Magainin 2
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概要
- 論文の詳細を見る
Based on the antibacterial activity of 9-phenylnonylamine (pC9a) against Escherichia coli (ATCC29522) and Staphylococcus aureus (ATCC25923), we have further tested the inhibitory ability of the growth of the bacteria by (±)1-(4-aminobutyl)-6-benzylindane (PM2) and (±)1-benzyl-6-(4-aminobutyl) indane (PM3), that is, two kinds of 1,6-disubstituted indanes. In an in vivo assay, they showed almost the same antibacterial activities against the bacteria as pC9a, as well as that of magainin 2 analogs (i.e., the peptides MSI-78 and 87-ISM), except in the case of 87-ISM against S. aureus. At the MIC (minimum inhibitory concentration) values, however, their killing rate of E.coli is actually quicker than pC9a. This indicates that an indane scaffold, used as a template to mimic a part of the α-helical structure of magainin 2,can accelerate the killing rate. At present, however, it is unknown wherther either the hydrophobicity or the α-helical structure, or both, of the indane scaffold is involved in accelerating the rate. Moreover, these two indanes also showed stronger antibacterial activity against two strains of Helicobacter pylori (ATCC43526,ATCC43579) than either pC9a or magainin 2 related peptides.
- 公益社団法人日本薬学会の論文
- 1997-07-15
著者
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Yamane Shinji
Sagami Chemical Research Center
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Iwahori A
Hoshi Univ. Tokyo Jpn
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NUMAO Naganori
BioFrontier Institute Inc.
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KOBAYASHI Susumu
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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Onimura Kenjiro
Sagami Chemical Research Center
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Kobayashi Susumu
Department Of Pharmaceutical Sciences Tokyo University Of Science
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Numao N
Biofrontier Institute Inc.
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Itoh Sachiko
Sagami Chemical Research Center
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Numao Naganori
Sagami Chemical Research Center
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Kobayashi S
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University:organizat
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KAMINO Tomoyuki
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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HIROTA Yukiko
Sagami Chemical Research Center
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IWAHORI Akiyo
Sagami Chemical Research Center
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SASATSU Masanori
Showa College of Pharmaceutical Sciences
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KONDO Isamu
the Jikei University School of Medicine
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KATOH Tadashi
Sagami Chemical Research Center
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SAMPE Ruriko
Sagami Chemical Research Center
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KOBAYASHI Susumu
Sagami Chemical Research Center
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Hirota Y
Sagami Chemical Research Center
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Sasatsu M
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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Kamino Tomoyuki
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Numao N
Biofrontier Inst. Inc.
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Sasatsu Masanori
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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