Cloning and Characterization of a Novel Chromosomal Drug Efflux Gene in Staphylococcus aureus
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概要
- 論文の詳細を見る
A novel drug efflux gene (named sepA, staphylococcal efflux pump gene) is cloned from antiseptic-resistant mutants of Staphylococcus aureus into Escherichia coli. The sepA gene conferred the reduction of susceptibility to acriflavine and the acceleration of ethidium bromide efflux from the E. coli cells. The sepA (474 bp) encoded the protein that has four predicted transmembrane segments. These results indicate that sepA gene is a multidrug-resistant gene and encodes a drug efflux protein.
- 公益社団法人 日本薬学会の論文
- 2002-12-01
著者
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NOGUCHI Norihisa
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Narui Koji
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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SASATSU Masanori
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Noguchi Norihisa
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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Noguchi Norihisa
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Noguchi Norihisa
Tokyo University Of Pharmacy And Life Science
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Sasatsu M
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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Sasatsu Masanori
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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WAKASUGI Kazunori
Division of Clinical Immunohaematology, Department of Internal Medicine, Tokyo Medical University at
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Wakasugi Kazunori
Division Of Clinical Immunohaematology Department Of Internal Medicine Tokyo Medical University At H
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Sasatsu Masanori
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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