Transduction of the Plasmid Encoding Antiseptic Resistance Gene qacB in Staphylococcus aureus(Microbiology)
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概要
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The plasmid-borne qacA and qacB genes encode a multidrug efflux protein. The proteins encoded by qacA and qacB mediate efflux of cationic antiseptic agents such as quaternary ammonium compounds. In methicillin-resistant Staphylococcus aureus (MRSA), qacA and qacB are widely prevalent and decrease antiseptic susceptibility. However, it is difficult to find the plasmids encoding qacA or qacB in community-associated MRSA (C-MRSA) isolated from patients with impetigo. Most MRSA, the strains causative of impetigo, carry the plasmidborne exfoliative toxin-producing gene etb. To find the reason for the paucity of qacA or qacB in MRSA isolated from patients with impetigo, we performed transfer experiments of the plasmid prTZ2162qacB encoding qacB. The pTZ2162qacB was transferred to S. aureus strain RN4220 by transduction, although no pTZ2162qacB was transferred by conjugation. Additionally, pTZ2162qacB was transduced to MRSA carrying etb, and was coexistence with the plasmid encoding etb. Our results showed that pTZ2162qacB was horizontally transferred by transduction and was compatible with the plasmid encoding etb. Consequently, there will be risk of the emergence of C-MRSA with decreased antiseptic susceptibility among patients with impetigo.
- 2007-08-01
著者
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NOGUCHI Norihisa
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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NAKAMINAMI Hidemasa
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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NISHIJIMA Setsuko
Department of Dermatology, Kori Hospital, Kansai Medical University
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KUROKAWA Ichiro
Department of Dermatology, Graduate School of Medicine, Mie University
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SO Hiromu
Department of Dermatology, Rakusai Newtown Hospital, Kansai Medical University
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SASATSU Masanori
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Noguchi Norihisa
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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Noguchi Norihisa
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Noguchi Norihisa
Tokyo University Of Pharmacy And Life Science
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So Hiromu
Department Of Dermatology Rakusai Newtown Hospital Kansai Medical University
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Sasatsu Masanori
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Nishijima Setsuko
Mie Univ. Mie Jpn
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Nishijima Setsuko
Department Of Dermatology Kansai Medical University Kori Hospital
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Kurokawa Ichiro
Nishijima Skin Clinic Osaka
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Kurokawa Ichiro
Department Of Dermatology Hyogo Prefectual Tsukaguchi Hospital
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Nakaminami Hidemasa
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Nishijima Setsuko
Department Of Dermatology Graduate School Of Medicine Mie University
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