N^ε- (Carboxymethyl) lysine Proliferated CD34^+ Cells from Rat Choroidal Explant in Culture(Pharmacology)
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概要
- 論文の詳細を見る
Action of N^ε- (carboxymethyl) lysine-human serum albumin (CML-HSA) on neovascularization was investigated in cultured rat choroidal explant. Choroidal explants of normal male Wistar rats were cultured in fibrin gel with Dulbecco's modified Eagle medium containing fetal bovine serum in the presence or absence of CML-HSA. Migrated cells were budded from 2nd day in culture and developed from cultured choroidal explants in a time-dependent manner. Budded and developed cells from the choroidal explant had a feature of fibroblasts, which had attenuated long cytoplasmic processes, long ellipsoid nuclei and numerous membrane-bound polymorphic vesicles. Immunostaining of the attenuated cells in fibrin bed with CD34 (a marker protein of vascular endothelial cells and endothelial progenitor cells) failed to disclose positive result. However the cells which were isolated from fibrin bed by collagenase were specifically stained with anti-CD34 antibody. The isolated cells did not form tube-like structures on collagen gel by 3 weeks in culture. CML-HSA significantly increased the number of total isolated cells and CD34^+ cells as well as the number of vessel-like structures. These results indicate that CML-HSA overproduced immature blood vessels from cultured choroidal explants in fibrin gel, which consisted of CD34^+ cells. The CML-HSA-induced formation of immature blood vessel may be implicated in various choroidal diseases such as age-related macular degeneration.
- 社団法人日本薬学会の論文
- 2004-09-01
著者
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Horiuchi Seikoh
Department of Biochemistry, Kumamoto University School of Medicine
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Horiuchi Seikoh
熊本大学 医学薬学研究部病態生化学
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Horiuchi S
Department Of Biochemistry Kumamoto University School Of Medicine
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Horiuchi Seikoh
帝京大学 薬
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Horiuchi Seikoh
Department Of Medical Biochemistry Kumamoto University Graduate School Of Medical Sciences
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KOBAYASHI Shinjiro
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University
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TSUNEKI Hiroshi
Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University
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NAGAI Ryoji
Department of Medical Biochemistry, Kumamoto University Graduate School of Medical Sciences
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SHINOHARA Harumichi
Department of Anatomy, Kanazawa Medical University
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Horiuchi Seikoh
Department Of Biochemistry Kumamoto University
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Kobayashi Shinjiro
Department Of Chemical Pharmacology Toyama Medical And Pharmaceutical University
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Tsuneki H
Department Of Clinical Pharmacology University Of Toyama
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Kobayashi S
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University:organizat
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Kobayashi S
Kyoritsu Coll. Pharmacy
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Horiuchi Seikoh
Biochemistry Kumamoto University School Of Medicine
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Nagai Ryoji
Department Of Biochemistry Kumamoto University
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Tsuneki Hiroshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Tsuneki Hiroshi
富山医科薬科大学大学院薬学研究科 臨床薬理学講座
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Kobayashi Shinjiro
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University:organizat
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Shinohara H
Department Of Anatomy Kanazawa Medical University
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Shinohara Harumichi
Department Of Anatomy Kanazawa Medical University
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TSUNEKI Hiroshi
Department of Clinical Pharmacology,Graduate School of Pharmaceutical Sciences,Toyama Medical and Pharmaceutical
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Kobayashi Shinjiro
Department of Applied Chemistry, Faculty of Engineering, Kyushu University
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