Acyl Coenzyme A : Cholesterol Acyltransferase(ACAT)in Macrophage-Derived Foam Cells and Its Distribution in Human Organs

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概要

• 論文の詳細を見る

• Acyl coenzyme A:cholesterol acyltransferase(ACAT)is a critical enzyme participating in both intracellular cholesterol homeostasis and systemic sterol metabolism and are classified into two ACAT-isozymes termed ACAT-1 and ACAT-2. In humans, ACAT-1 is expressed ubiquitously in a variety of cells such as macrophages, enterocytes/hepatocytes, and steroid hormone-producing cells. In macrophages, immunoelectron microscopic examination revealed that ACAT-1 is localized in the endoplasmic reticulum(ER). When the cells are exposed to modified low density lipoprotein to induce foam cell transformation, a portion of ACAT-1 is shifted from ER to ER-derived small vesicles. The histological distribution of ACAT-2 in humans is still unclear, but recent data demonstrated that this isozyme is expressed in enterocytes.

• 日本組織細胞化学会の論文

著者

• Chang Cathrine

  Department of Biochemistry, Dartmouse Medical School

• Chang Ta-Yuan

  Department of Biochemistry, Dartmouse Medical School

• MIYAZAKI Akira

  Department of Biochemistry, Showa University School of Medicine

• Sakaino Naritsugu

  国家公務員共済組合連合会総合病院熊本中央病院 循環器科

• Takeya Motohiro

  Second Department of Pathology, Kumamoto University School of Medicine

• Takahashi Kiyoshi

  Second Department of Pathology, Kumamoto University School of Medicine

• Takeya M

  Second Department Of Pathology Kumamoto University School Of Medicine

• Takeya Motohiro

  Kumamoto Univ. Kumamoto Jpn

• Sakashita Naomi

  Second Department of Pathology

• Horiuchi Seikoh

  Department of Biochemistry, Kumamoto University School of Medicine

• Horiuchi S

  Department Of Biochemistry Kumamoto University School Of Medicine

• Horiuchi Seikoh

  Department Of Biochemistry Kumamoto University School Of Medicine

• Horiuchi Seikoh

  Department Of Medical Biochemistry Graduate School Of Medical And Pharmaceutical Sciences Kumamoto U

• Horiuchi Seikoh

  帝京大学 薬

• Chang Ta-yuan

  熊本大学 第2病理

• Chang Ta-yuan

  Department Of Biochemistry Dartmouth Medical School

• Chang Cathrine

  熊本大学 第2病理

• Chang Cathrine

  Department Of Biochemistry Dartmouth Medical School

• Miyazaki Akira

  熊本大学 薬 生体機能化学

• Takeya Motohiro

  Second Department Of Pathology Kumamoto University Medical School

• Horiuchi Seikoh

  Department Of Medical Biochemistry Graduate School Of Medical Sciences Kumamoto University

• Horiuchi Seikoh

  Department Of Biochemistry Kumamoto University

• Takahashi Kiyoshi

  Fuji Bio Co. Ltd.

• Takahashi K

  Fuji Bio Co. Ltd.

• Takahashi K

  Research Institute For Applied Mechanics Kyushu University

• Murayama Toshihiko

  Division Of Surgical Pathology National Hospital Organization Kumamoto Medical Center

• Miyazaki Akira

  Department Of Biochemistry Kumamoto University School Of Medicine

• Takeya Motohiro

  Department Of Gastroenterological Surgery Graduate School Of Medical Sciences Kumamoto University

• Miyazaki Akira

  Department Of Biochemistry Faculty Of Medicine Showa University

• Takahashi Kiyoshi

  Second Department Of Pathology Kumamoto University Medical School

• Horiuchi Seikoh

  Department Of Medical Biochemistry Graduate School Of Medical And Pharmaceutical Sciences Kumamoto U

• MIYAZAKI Akira

  Department of Biochemistry, Kumamoto University School of Medicine

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