Effect of AGEs on Human Disc Herniation: Intervertebral Disc Hernia Is Also Effected by AGEs
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概要
- 論文の詳細を見る
Currently, extracellular matrix MMP has been discussed in relation to the extrusion and spontaneous regression of the herniated mass observed in lumbar disc herniation. However, the question remains as to whether degenerated protein is really the cause of this conditions pathogenesis. We confirmed immunologically by means of electron microscopy that extrusion is caused by the AGEs (advanced glycation end products)-induced cross-linking of collagen, and that spontaneous regression is due to AGE receptors on macrophages. Further, AGEs were found to be already exposed during histogenesis, suggesting a relation to apoptosis. In lumbar disc herniation and aging, glucose-derived AGEs cross-link proteins and cause vascular tissue damage.
著者
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YAMADA Akira
Departments of Immunology, Kurume University School of Medicine
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SATA Michio
Department of Digestive Disease Information & Research
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Yamada Akira
Department Of Cardiology Aso-iizuka Hospital
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Jimi Atsuo
Department Of Pathology Kurume University Medical Center
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Horiuchi Seikoh
Department Of Biochemistry Kumamoto University
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Nagata Kensei
Department Of Orthopaedic Surgery Kurume University
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Nagai Ryoji
Department Of Biochemistry Kumamoto University
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NAGAI RYOJI
Department of Biochemistry, Kumamoto University Medical School
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TSURU MICHIYO
Departments of Orthopaedic Surgery, Kurume University School of Medicine
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IRIE KOUJI
Department of Pathology, Kouseikan Hospital
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NAGATA KENSEI
Department of Orthopaedic Surgery ,Kurume University School of Medicine
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SATA MICHIO
Departments of Medicine, Kurume University School of Medicine
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JIMI ATSUO
Department of Pathology and Oncology, University of Occupational and Environmental Health, Japan, School of Medicine
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