Extracellular-Added ADP-Ribose Increases Intracellular Free Ca^<2+> Concentration Through Ca^<2+> Release From Stores, but Not Through TRPM2-Mediated Ca^<2+> Entry, in Rat β-Cell Line RIN-5F

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概要

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• Intracellular ADP-ribose is an activator of TRPM2, which is a Ca2+-permeable channel and mediates H2O2-induced cell death, in the TRPM2-expressing rat β-cell line RIN-5F. We examined the effect of extracellular-added ADP-ribose on intracellular Ca2+ concentration in RIN-5F cells. ADP-ribose induced Ca2+ release from the thapsigargin-sensitive Ca2+ store, but not Ca2+ entry across the plasma membrane. A phospholipase C (PLC) inhibitor and a non-specific IP3 receptor inhibitor blocked its Ca2+ release. H2O2-induced Ca2+ entry through TRPM2 was not affected by extracellular ADP-ribose. These findings suggest that extracellular-added ADP-ribose induces Ca2+ release through the PLC-IP3 pathway and does not act as a TRPM2 activator.

• 社団法人 日本薬理学会の論文
• 2006-06-20

著者

• ISHII Masakazu

  Department of Cardiology, Nagoya University Graduate School of Medicine

• MIYAZAKI Akira

  Department of Biochemistry, Showa University School of Medicine

• Mori Y

  Center For Integrative Bioscience Okazaki National Research Institutes

• Ishii Masakazu

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Ishii Masakazu

  Department Of Pathophysiology School Of Pharmacy Showa University

• Ishii Masakazu

  Center For Integrative Bioscience Okazaki National Research Institutes

• Miyazaki A

  Faculty Of Agriculture Kochi University

• Yasuda Masako

  Laboratory Of Molecular Biology Department Of Synthetic And Biological Chemistry Graduate School Of

• SHIMIZU Shunichi

  Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University

• HAGIWARA Tamio

  Department of Biochemistry, Showa University School of Medicine

• WAJIMA Teruaki

  Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University

• MORI Yasuo

  Laboratory of Molecular Biology, Department of Synthetic and Biological Chemistry, Graduate School o

• KIUCHI Yuji

  Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University

• Kiuchi Yuji

  Center Of Pharmaceutical Education School Of Pharmacy Showa Univ.

• Kiuchi Y

  Department Of Electronic Engineering Faculty Of Technology Tokyo University Of Agriculture And Techn

• Kiuchi Yuji

  Department Of Electronic Engineering Faculty Of Technology Tokyo University Of Agriculture And Techn

• Wajima Teruaki

  Department Of Pathophysiology School Of Pharmaceutical Sciences Showa University

• Hagiwara Tamio

  Department Of Biochemistry Showa University School Of Medicine

• Miyazaki Akira

  Department Of Biochemistry Kumamoto University School Of Medicine

• Masuda Yutaka

  Department Of Anesthesiology School Of Medicine

• Shimizu Shunichi

  Dep. Of Pathophysiology School Of Pharmacy Showa Univ.

• Miyazaki Akira

  Department Of Biochemistry Faculty Of Medicine Showa University

• Mori Yasuo

  Laboratory Of Food Chemistry Faculty Of Fisheries Kagoshima University

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