The Response to Acoustic Stimulation and the Changes in Brain Amine Levels after Repeated Administration of .BETA.-Phenylethylamine in Rats.
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概要
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Reverse tolerance to stereotyped behavior was induced after repeated administration of β-phenylethylamine (PEA) (50 mg/kg, i.p., daily for 10 days) in rats. The reverse tolerance was maintained for at least 4 weeks after the last administration. We studied the effects of acoustic stimulation on locomotor activity 2 days and 4 weeks after withdrawal from PEA and measured the changes in brain monoamine levels 4 weeks after the withdrawal. Locomotor activity during acoustic stimulation was increased in the saline treated group, and this response was unaffected after repeated PEA treatment. Four weeks after withdrawal, significant increases in noradrenaline levels in the cerebral cortex and decreases in 5-hydroxytryptamine levels in the hypothalamus were found. The effects of acoustic stimulation on locomotor activity and the changes in brain monoamine levels were different from those of methamphetamine treatment obtained in our previous study. In conclusion, it may be suggested that the response to acoustic stimulation after repeated PEA administration in rats cannot be a model for abnormal responsiveness to environmental stimulation that is observed in chronic paranoid schizophrenics.
- 公益社団法人 日本薬理学会の論文
著者
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Oguchi Katsuji
Department Of Pharmacology School Of Medicine Showa University
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Kiuchi Yuji
Department Of Electronic Engineering Faculty Of Technology Tokyo University Of Agriculture And Techn
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Yamada Mitsuhiko
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Yasuhara Hajime
Department Of Neonatal Intensive Care Unit Nara Prefectural Hospital
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HASHIMOTO Miyuki
Department of Pharmacology, School of Medicine, Showa University
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Yamada Mitsuhiko
Department of Pharmacology, School of Medicine, Showa University
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