Effect of a Dihydrobenzofuran Derivative on Lipid Hydroperoxide-Induced Rabbit Corneal Neovascularization
スポンサーリンク
概要
- 論文の詳細を見る
The aim of this study was to investigate the effect of A-3922, a dihydrobenzofuran derivative, on linoleic acid hydroperoxide (LHP)-induced corneal neovascularization (NV) in a rabbit model. Male New Zealand rabbits received intraperitoneal (i.p.) injections of 10 or 30 mg/kg per day A-3922 or its vehicle as control for 3 days. One day after i.p. injections, LHP was injected with a 30-gauge needle into the corneal stroma of the superior quadrant 4.5-mm below the limbus. Photographs of the vessels were taken for digital analysis with a surgical microscope. Vascular endothelial growth factor (VEGF) was measured using an immunoassay kit, and matrix metalloproteinase (MMP)-9 was measured by gelatin zymography in corneal samples. At 7 days post-LHP injection, the total vessel length was 26.7 ± 3.8 mm in the control animals (n = 8), 16.1 ± 0.8 mm in the A-3922 (10 mg/kg)-treated group (n = 5), and 11.4 ± 2.1 mm in the 30 mg/kg group (n = 8, P<0.01 vs control), respectively. After LHP injection, the content of VEGF and MMP-9 activity were increased in the superior cornea, but these were not influenced by A-3922 treatments. These results indicate that LHP-induced corneal NV is inhibited by treatment with A-3922 and therefore may represent a potential pharmacological intervention for ocular neovascularization disorders.
- 社団法人 日本薬理学会の論文
- 2007-02-20
著者
-
ARMSTRONG Donald
Department of Opthalmology, School of Medicine, Showa University
-
YASUHARA Hajime
Department of Pharmacology, School of Medicine, Showa University
-
Armstrong Donald
昭和大学 医学部第一薬理学教室
-
Yasuhara Hajime
Department Of Second Pharmacology Showa University School Of Medicine
-
Yasuhara Hajime
Department Of Pharmacology School Of Medicine Showa University
-
OGUCHI KATSUJI
Department of Pharmacology, School of Medicine, Showa University
-
Armstrong Donald
Department Of Ophthalmology School Of Medicine Showa University
-
Koide Ryohei
Department of Ophthalmology, Showa University School of Medicine
-
OGURA Hirotsugu
Department of Ophthalmology, School of Medicine, Showa University
-
NAKANISHI UEDA
Department of Pharmacology, School of Medicine, Showa University
-
UEDA Toshihiko
Department of Ophthalmology, School of Medicine, Showa University
-
IWAI Shinichi
Department of Pharmacology, School of Medicine, Showa University
-
UCHIDA Seiichi
Department of Biological Research, Division 2, Odawara Research Center, Nippon Soda, Co., Ltd.
-
SAITO Yuta
Department of Ophthalmology, School of Medicine, Showa University
-
TAGUCHI Yoko
Department of Ophthalmology, School of Medicine, Showa University
-
Koide Ryohei
Department Of Ophthalmology School Of Medicine Showa University
-
Oguchi Katsuji
Department Of Pharmacology School Of Medicine Showa University
-
Koide Ryohei
Department Of Ophthalmology Showa University School Of Medicine
-
Nakanishi Ueda
Department Of Pharmacology School Of Medicine Showa University
-
Armstrong Donald
Department Of Clinical Laboratory Science University At Buffalo
-
Saito Yuta
Department Of Ophthalmology School Of Medicine Showa University
-
Taguchi Yoko
Department Of Ophthalmology Fujigaoka Rehabilitation Hospital Showa University School Of Medicine
-
Iwai Shinichi
Department Of Pharmacology School Of Medicine Showa University
-
Uchida Seiichi
Department Of Biological Research Division 2 Odawara Research Center Nippon Soda Co. Ltd.
-
Ueda Toshihiko
Department Of Ophthalmology School Of Medicine Showa University
-
Ueda Toshihiko
Department Of Cardiovascular Surgery Keio University
-
Ueda Toshihiko
Department Of Clinical Laboratory Science University At Buffalo
-
Ogura Hirotsugu
Department Of Ophthalmology School Of Medicine Showa University
-
Yasuhara Hajime
Department Of Pharmacology School Of Medicine
-
Taguchi Yoko
Department Of Ophthalmology School Of Medicine Showa University
-
Yasuhara Hajime
Showa Univ. School Of Medicine Tokyo Jpn
-
Yasuhara Hajime
Department Of Pediatrics Yao Municipal Hospital
-
Yasuhara Hajime
Department Of Neonatal Intensive Care Unit Nara Prefectural Hospital
-
Saito Yuta
Department Of Innovative And Engineered Materials Tokyo Institute Of Technology
-
Nakanishi-Ueda Takako
Department of Pharmacology, School of Medicine, Showa University
-
Nakanishi-Ueda Takako
Department of Ophthalmology, School of Medicine, Showa University
-
Saito Yuta
Department of General Internal Medicine, Aso Iizuka Hospital
関連論文
- 過酸化脂質誘導ウサギ網膜血管新生モデルにおけるアクチベータープロテイン-1(AP-1)とマトリックスメタロプロテナーゼ(MMP)の変化
- 過酸化脂質誘導ウサギ網膜血管新生モデルの網膜におけるMMPおよびTIMP mRNAのリアルタイムPCRによる解析
- 過酸化脂質誘導ウサギ角膜血管新生モデルにおけるビタミンEの効果
- 青色発光ダイオード光による網膜障害
- ウシ網膜ホモジネートのラジカル惹起剤誘導脂質過酸化反応に対する各種抗酸化剤の効果の比較
- 過酸化脂質による角膜新生血管の定量的解析法
- ウサギ角膜血管新生モデルにおける柴苓湯, 五苓散, 小柴胡湯の効果
- P-11 角膜新生血管モデルにおける柴苓湯, 五苓散または小柴胡湯の効果
- P-7 柴苓湯による角膜および網膜新生血管抑制作用
- Antidiabetic effects of Kampo medicines in a non-insulin-dependent diabetes mellitus model using KK-Ay mice
- Intrathecally Administered D-Cycloserine Produces Nociceptive Behavior Through the Activation of N-Methyl-D-aspartate Receptor Ion-Channel Complex Acting on the Glycine Recognition Site
- SELECTIVE INHIBITION OF HEPATIC DRUG OXIDIZING ENZYMES BY 480156-S IN MAN
- TRIMETHADIONE TOLERANCE TEST FOR EVALUATION OF FUNCTIONAL RESERVE OF THE LIVER IN PATIENTS WITH LIVER CIRRHOSIS AND ESOPHAGEAL VARICES
- THE EFFECT OF INDOMETHACIN ON HEPATIC DRUG-OXIDIZING CAPACITY IN THE RAT : TRIMETHADIONE AND ANTIPYRINE METABOLISM AS AN INDICATOR
- A METHOD FOR ESTIMATION OF HEPATIC DRUG-METABOLIZING CAPACITY : DETERMINATION OF CONCENTRATION OF TRIMETHADIONE AND ITS METABOLITE IN HUMAN SERUM
- In Vitro Assessment of the Cytotoxicity of Anti-allergic Eye Drops Using 5 Cultured Corneal and Conjunctival Cell Lines
- Effect of a Dihydrobenzofuran Derivative on Lipid Hydroperoxide-Induced Rabbit Corneal Neovascularization
- Induction of heat shock protein (hsp 70) in human lymphocytes by Kampo herbal medicine
- Impaired Contact Hypersensitivity Reaction and Reduced Production of Vascular Endothelial Growth Factor in Tumor Necrosis Factor-α Gene-Deficient Mice
- Effects of Lipid Peroxidation (LP) in Mouse Liver, Spleen and Brain after whole-body Irradiation and Radioprotective effects of Dipyridainole.
- Effect on the lipid peroxide level in the post-irradiated aged mice and protection post-irradiated aged mice by dipyridamole.
- Cytotoxicity of Topical Medications Used for Infection and Inflammation Control after Cataract Surgery in Cultured Corneal Endothelial Cells
- Enantioselective determination of azelnidipine in human plasma using liquid chromatography-tandem mass spectrometry
- Effects of Continuous Ingestion of Herbal Teas on Intestinal CYP3A in the Rat
- Effect of a Single Glass of Grapefruit Juice on the Apparent Oral Bioavailability of the Dihydropyridine Calcium Channel Antagonist, Azelnidipine, in Healthy Japanese Volunteers
- A Clinical Pharmacological Study to Evaluate the Sedative Effects of the Antihistaminic Drug, Diphenhydramine Hydrochloride (Drewell^【○!R】) : Objective Evaluation of the Sedative Effects by Analysis of Saccadic Eye Movement
- Inhibitory Effect of Antituberculosis Drugs on Human Cytochrome P450-Mediated Activities
- Contribution of Non-renal Clearance to the Elimination of Vancomycin during Repeated Intravenous Administration in Elderly Patients
- Changes of Hepatic Microsomal Oxidative Drug Metabolizing Enzymes in Chronic Renal Failure (CRF) Rats by Partial Nephrectomy
- Attenuation of Cataract Progression by A-3922, a Dihydrobenzofuran Derivative, in Streptozotocin-Induced Diabetic Rats(Pharmacology)
- DRUG POISONING : ADVERSE REACTION
- In vivo Screening test for antioxidant drugs using 8 Gy whole-body irradiated mice
- EFFECT OF DIMETHYL SULFOXIDE PRETREATMENT ON ACTIVITIES OF LIPID PEROXIDE FORMATION, SUPERROXIDE DISMUTASE AND GLUTATHIONE PEROXIDASE IN THE MOUSE LIVER AFTER WHOLE-BODY IRRADIATION
- Vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK 222584 inhibits both the induction and elicitation phases of contact hypersensitivity
- Sequential Induction of Growth Factors In Lipid Peroxide Activated Retinal Neovascularization : A Model For Proliferative Diabetic Retinopathy
- Recurrent discrete subaortic stenosis and small aortic annulus successfully repaired by the Konno procedure in young woman
- Effect of Post-Ischemic Hypothermia on Spinal Cord Damage induced by Transient Ischemic Insult in Rabbits
- A Chemically Amplified, Negative-type Photosensitive Poly(phenylene ether ketone) (PEK) Resist Based on Ketal-protected PEK and a Photoacid Generator
- Automatic Classification of Spatial Relationships among Mathematical Symbols Using Geometric Features
- Endoluminal Stent-grafting for Thoracoabdominal Aortic Aneurysm in Takayasu's Disease
- Surgical Treatment of a Distal Arch Pseudoaneurysm and Migrated Stent-graft after Interrupted Aortic Arch Repair
- ANALYSES OF ACTIVE SUBSTANCES DYNAMICS IN THE CENTRAL NORADRENERGIC, DOPAMINERGIC, SEROTONERGIC, CHOLINERGIC AND AMINO ACIDERGIC NERVOUS SYSTEMS BY HPLC-MULTIPLE COULOMETRIC ECD
- Esophageal Perforation of Aortic Arch Aneurysm Treated Free of Mediastinitis without Manipulating Esophagus
- INHIBITION OF CARP LIVER MITOCHONDRIAL MONOAMINE OXIDASE BY SOME COMMONLY-USED DETERGENTS
- Neuroprotective Effects of N-methyl-D-aspartate Receptor Antagonist on Aspartate Induced Neurotoxicity in the Spinal Cord in vivo
- Regulation of dopamine uptake by basic fibroblast growth factor and epidermal growth factor in cultured rat astrocytes
- Effect of Delayed Induction of Postischemic Hypothermia on Spinal Cord Damage Induced by Transient Ischemic Insult in Rabbits
- Effects of Pioglitazone on Increases in Visceral Fat Accumulation and Oxidative Stress in Spontaneously Hypertensive Hyperlipidemic Rats Fed a High-Fat Diet and Sucrose Solution
- Enhancement of the Coagulation System in Spontaneously Hypertensive and Hyperlipidemic Rats
- Inhibitory Effects of Sasa senanensis Rehder Extract (SE) on Calcium-Ionophore A23187 : Induced Histamine Release From Rat Peritoneal Exudate Cells
- Novel Mutations in C-terminal Channel Region of the Ryanodine Receptor in Malignant Hyperthermia Patients
- STUDIES ON β-PHENYLETHYLAMINE DEAMINATION BY HUMAN PLACENTAL MONOAMINE OXIDASE
- Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice
- STUDIES ON HUMAN PLACENTAL MONOAMINE OXIDASE USING MIXED SUBSTRATES
- Association of the A-1438G Polymorphism in Serotonin 2A Receptor in Migraine with Aura among Japanese Patients
- DEPRESSED RESPIRATION INDUCED BY INTRAVENOUSLY ADMINISTERED DOPAMINE IN ANESTHETIZED DOGS
- EXPERIMENTAL HYPERLIPIDEMIA AND ATHEROSCLEROSIS INDUCED BY CHOLESTEROL DIET IN SPF JAPANESE WHITE RABBITS
- Preserved and Unpreserved 12 Anti-allergic Ophthalmic Solutions and Ocular Surface Toxicity : In Vitro Assessment in Four Cultured Corneal and Conjunctival Epithelial Cell Lines
- Diabetic Nephropathy in KK and KK-A^y Mice
- Age-Related Changes in Blood Coagulation and Fibrinolysis in Mice Fed on a High-Cholesterol Diet
- Polyhydroxyalkanoate (PHA) Synthesis by Class IV PHA Synthases Employing Ralstonia eutropha PHB−4 as Host Strain
- In Vivo Inhibition of CYP3A-Mediated Midazolam Metabolism by Anchusan in Rats
- Study on SAW Streaming and its Application to Fluid Devices : SAW and Communication Devices
- Transient immunoglobulin-complexed aspartate aminotransferase in infancy caused by maternal immunoglobulin G
- 仮死は成熟児における啼泣後の呼吸抑制の原因となるか?
- 新生児の啼泣後の呼吸抑制の効果的なスクリーニング方法
- Polyhydroxyalkanoate (PHA) Synthesis by Class IV PHA Synthases Employing Ralstonia eutropha PHB^-4 as Host Strain
- A case of retinal light damage by green laser pointer (Class 3b)
- In Vivo Inhibition of CYP3A-Mediated Midazolam Metabolism by Anchusan in Rats
- Surgical Outcome of Blowout Fracture : Early Repair Without Implants and the Usefulness of Balloon Treatment
- MECHANISM OF MEMBRANE STABILIZING AND LYTIC EFFECTS OF TRICYCLIC ANTIDEPRESSANTS
- HEMODYNAMICS AND MONOAMINE OXIDASE ACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR)
- EFFECTS OF LOCAL ANESTHETICS ON MONOAMINE OXIDASE, AND THEIR MEMBRANE EFFECTS
- Operative Procedures and Surgical Outcome of the Patients Undergoing Repair of the Ascending Aorta and/or Transverse Aortic Arch
- ERYTHROCYTOSIS IN THIAMINE DEFICIENT RATS
- RELATIONSHIP BETWEEN THIAMINE AND GLUCOSE LEVELS IN DIABETES MELLITUS
- Changes in Coagulative and Fibrinolytic Activities in Triton WR-1339-Induced Hyperlipidemia in Rats
- Ultraviolet Action Spectrum for Cell Killing of Primary Porcine Lens Epithelial Cells
- Tea Polyphenols Inhibit Rat Osteoclast Formation and Differentiation
- Effect of salts on mitochondrial monoamine oxidase from bovine liver.
- Effects of ranitidine, metoclopromide, and anisotropine methylbromide on the availability of cefpodoxime proxetil (CS-807) in Japanese Healthy subjects.
- Pharmacokinetics of cefmetazole in elderly patients and healthy volunteers.
- Development of Hyperfibrinogenemia in Spontaneously Hypertensive and Hyperlipidemic Rats: A Potentially Useful Animal Model as a Complication of Hypertension and Hyperlipidemia
- Effect of caerulein with haloperidol on monoamine contents in rat brain regions treated with methamphetamine.
- The Response to Acoustic Stimulation and the Changes in Brain Amine Levels after Repeated Administration of .BETA.-Phenylethylamine in Rats.
- Protective effect of S-adenosyl-L-methionine against CCl4-induced hepatotoxicity in cultured hepatocytes.
- Protective effects of S-adenosyl-L-methionine against enzyme leakage from cultured hepatocytes and hypotonic hemolysis.
- The effects of amiflamine, a reversible MAO-A inhibitor, on the first pass metabolism of tyramine in dog intestine.
- Changes in brain lipid composition in thiamine deficient rats.
- Sustained Increase in Adrenergic Activity in Gerbil Striatum Following Transient Ischemia.
- Mechanisms of the Hypolipidemic Effect of NIP-200 in Rats.
- Clinical Problem Solving: Does This Patient Have Encephalopathy?
- Comparative Study of Amine Receptor Stimulated CAMP Formations in the Brain of Spontaneously Hypertensive Rat
- Antipyrine metabolism in female Lewis and Dark Agouti strains of rats, which are extensive and poor metabolizers of debrisoquine, respectively.
- Properties of monoamine oxidase in monkey heart.
- Effect of chronic treatment of propranolol on lipid metabolism in spontaneously hypertensive rats (SHR).
- A bioequivalence study of two different crystalline forms of malotilate: A and B.
- Hemodynamics and Monoamine Oxidase Activity in Spontaneously Hypertensive Rat (SHR)
- Correlation between Plasma Fibrinogen and Serum Lipids in Rats with Hyperlipidemia Induced by Cholesterol Free-High Fructose or High Cholesterol Diet.
- Brain swelling in acute superior vena cava syndrome due to aortic dissection : unusual and lethal manifestation aggravated by induction of general anesthesia