Changes in Coagulative and Fibrinolytic Activities in Triton WR-1339-Induced Hyperlipidemia in Rats
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概要
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Changes in coagulative and fibrinolytic activities were studied in rats with hyperlipidemia induced by Triton WR-1339 (T-WR). After intravenous injection of T-WR (150, 200 or 300 mg/kg) into S.D. rats, dose-related increases in plasma lipids (total cholesterol, triglyceride, free cholesterol and phospholipid) were observed. In hyperlipidemic rats that received 300 mg/kg of T-WR, decreases in red blood cell count and Hb value were found. Significant increases in the ma value of the thromboelastogram and the fibrinogen level were observed in these T-WR treated rats. The α<SUB>2</SUB>-plasmin inhibitor activity was found to decrease doserelatedly. These results indicate that T-WR induced hyperlipidemia in rats is accompanied with an increase in coagulative activity and an indirect enhancement of fibrinolytic activity.
著者
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Oguchi Katsuji
Department Of Pharmacology School Of Medicine Showa University
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Okazaki Masako
Department Of Orthodontics School Of Dentistry University Of Tokushima
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Suzuki Makoto
Department Of Cardiology Ehime Central Prefectual Hospital
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SUZUKI Makoto
Department of Pharmacology, School of Medicine, Showa University
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